Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

Giuseppe Montalto, Monica Notarbartolo Di Villarosa, Melchiorre Cervello, Giulia Ramazzotti, Alberto M. Martelli, Saverio Candido, Bruno Bueno-Silva, Stefano Ratti, Severino Matias De Alencar, Agnieszka Gizak, Kvin Lertpiriyapong, Dariusz Rakus, Pedro L. Rosalen, Massimo Libra, Shaw M. Akula, Linda S. Steelman, Marco Falasca, James A. Mccubrey, Ramiro M. Murata, Lucio CoccoGiuseppe Montalto, Matilde Y. Follo, Stephen L. Abrams

Risultato della ricerca: Article

Abstract

Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of β-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining β-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of β-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving β-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.
Lingua originaleEnglish
Numero di pagine15
RivistaAdvances in Biological Regulation
Stato di pubblicazionePublished - 2019

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Dietary Supplements
Pancreatic Neoplasms
Estradiol
Signal Transduction
Adenocarcinoma
Pharmaceutical Preparations
Estrogen Receptors
Drug Therapy
Growth
Biological Products
Radio
Therapeutics
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

Cita questo

Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells. / Montalto, Giuseppe; Notarbartolo Di Villarosa, Monica; Cervello, Melchiorre; Ramazzotti, Giulia; Martelli, Alberto M.; Candido, Saverio; Bueno-Silva, Bruno; Ratti, Stefano; Matias De Alencar, Severino; Gizak, Agnieszka; Lertpiriyapong, Kvin; Rakus, Dariusz; Rosalen, Pedro L.; Libra, Massimo; Akula, Shaw M.; Steelman, Linda S.; Falasca, Marco; Mccubrey, James A.; Murata, Ramiro M.; Cocco, Lucio; Montalto, Giuseppe; Follo, Matilde Y.; Abrams, Stephen L.

In: Advances in Biological Regulation, 2019.

Risultato della ricerca: Article

Montalto, G, Notarbartolo Di Villarosa, M, Cervello, M, Ramazzotti, G, Martelli, AM, Candido, S, Bueno-Silva, B, Ratti, S, Matias De Alencar, S, Gizak, A, Lertpiriyapong, K, Rakus, D, Rosalen, PL, Libra, M, Akula, SM, Steelman, LS, Falasca, M, Mccubrey, JA, Murata, RM, Cocco, L, Montalto, G, Follo, MY & Abrams, SL 2019, 'Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells', Advances in Biological Regulation.
Montalto, Giuseppe ; Notarbartolo Di Villarosa, Monica ; Cervello, Melchiorre ; Ramazzotti, Giulia ; Martelli, Alberto M. ; Candido, Saverio ; Bueno-Silva, Bruno ; Ratti, Stefano ; Matias De Alencar, Severino ; Gizak, Agnieszka ; Lertpiriyapong, Kvin ; Rakus, Dariusz ; Rosalen, Pedro L. ; Libra, Massimo ; Akula, Shaw M. ; Steelman, Linda S. ; Falasca, Marco ; Mccubrey, James A. ; Murata, Ramiro M. ; Cocco, Lucio ; Montalto, Giuseppe ; Follo, Matilde Y. ; Abrams, Stephen L. / Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells. In: Advances in Biological Regulation. 2019.
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title = "Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells",
abstract = "Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of β-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining β-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of β-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving β-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.",
author = "Giuseppe Montalto and {Notarbartolo Di Villarosa}, Monica and Melchiorre Cervello and Giulia Ramazzotti and Martelli, {Alberto M.} and Saverio Candido and Bruno Bueno-Silva and Stefano Ratti and {Matias De Alencar}, Severino and Agnieszka Gizak and Kvin Lertpiriyapong and Dariusz Rakus and Rosalen, {Pedro L.} and Massimo Libra and Akula, {Shaw M.} and Steelman, {Linda S.} and Marco Falasca and Mccubrey, {James A.} and Murata, {Ramiro M.} and Lucio Cocco and Giuseppe Montalto and Follo, {Matilde Y.} and Abrams, {Stephen L.}",
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TY - JOUR

T1 - Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

AU - Montalto, Giuseppe

AU - Notarbartolo Di Villarosa, Monica

AU - Cervello, Melchiorre

AU - Ramazzotti, Giulia

AU - Martelli, Alberto M.

AU - Candido, Saverio

AU - Bueno-Silva, Bruno

AU - Ratti, Stefano

AU - Matias De Alencar, Severino

AU - Gizak, Agnieszka

AU - Lertpiriyapong, Kvin

AU - Rakus, Dariusz

AU - Rosalen, Pedro L.

AU - Libra, Massimo

AU - Akula, Shaw M.

AU - Steelman, Linda S.

AU - Falasca, Marco

AU - Mccubrey, James A.

AU - Murata, Ramiro M.

AU - Cocco, Lucio

AU - Montalto, Giuseppe

AU - Follo, Matilde Y.

AU - Abrams, Stephen L.

PY - 2019

Y1 - 2019

N2 - Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of β-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining β-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of β-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving β-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.

AB - Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of β-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining β-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of β-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving β-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.

UR - http://hdl.handle.net/10447/391049

M3 - Article

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

SN - 2212-4926

ER -