Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.

Viviana Bazan; Fabio Fulfaro; Gianni Pantuso; Rosa Maria Tomasino; Antonio Russo; Vincenza Morello; Massimo Cajozzo; Valentina Agnese; Laura Ottini; null Colucci; Chiara Intrivici; Donatella Calcara

Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.

Viviana Bazan, Fabio Fulfaro, Gianni Pantuso, Rosa Maria Tomasino, Antonio Russo, Vincenza Morello, Massimo Cajozzo, Valentina Agnese, Laura Ottini, Colucci, Chiara Intrivici, Donatella Calcara

Risultato della ricerca: Article

20 Citazioni (Scopus)

Abstract

Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive microsatellite sequences during replication of DNA. Aberrant methylation is related to microsatellite instability (MSI) by the silencing of the hMLH1 gene. The aim of this study is to investigate a possible relationship between the RUNX3 promoter methylation, nuclear microsatellite instability (nMSI) and mitochondrial microsatellite instability (mtMSI), in order to clarify its biological role in GC.

Lingua originale	English
pagine (da-a)	103-109
Rivista	Annals of Oncology
Volume	18 Suppl 6
Stato di pubblicazione	Published - 2007

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Bazan, V., Fulfaro, F., Pantuso, G., Tomasino, R. M., Russo, A., Morello, V., Cajozzo, M., Agnese, V., Ottini, L., Colucci, Intrivici, C., & Calcara, D. (2007). Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. Annals of Oncology, 18 Suppl 6, 103-109.

Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. / Bazan, Viviana ; Fulfaro, Fabio ; Pantuso, Gianni et al.
In: Annals of Oncology, Vol. 18 Suppl 6, 2007, pag. 103-109.

Risultato della ricerca: Article

Bazan, V , Fulfaro, F , Pantuso, G , Tomasino, RM , Russo, A , Morello, V , Cajozzo, M , Agnese, V, Ottini, L, Colucci, Intrivici, C & Calcara, D 2007, 'Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.', Annals of Oncology, vol. 18 Suppl 6, pagg. 103-109.

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abstract = "Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive microsatellite sequences during replication of DNA. Aberrant methylation is related to microsatellite instability (MSI) by the silencing of the hMLH1 gene. The aim of this study is to investigate a possible relationship between the RUNX3 promoter methylation, nuclear microsatellite instability (nMSI) and mitochondrial microsatellite instability (mtMSI), in order to clarify its biological role in GC.",

author = "Viviana Bazan and Fabio Fulfaro and Gianni Pantuso and Tomasino, {Rosa Maria} and Antonio Russo and Vincenza Morello and Massimo Cajozzo and Valentina Agnese and Laura Ottini and Colucci and Chiara Intrivici and Donatella Calcara",

year = "2007",

language = "English",

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T1 - Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.

AU - Bazan, Viviana

AU - Fulfaro, Fabio

AU - Pantuso, Gianni

AU - Tomasino, Rosa Maria

AU - Russo, Antonio

AU - Morello, Vincenza

AU - Cajozzo, Massimo

AU - Agnese, Valentina

AU - Ottini, Laura

AU - Colucci, null

AU - Intrivici, Chiara

AU - Calcara, Donatella

PY - 2007

Y1 - 2007

N2 - Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive microsatellite sequences during replication of DNA. Aberrant methylation is related to microsatellite instability (MSI) by the silencing of the hMLH1 gene. The aim of this study is to investigate a possible relationship between the RUNX3 promoter methylation, nuclear microsatellite instability (nMSI) and mitochondrial microsatellite instability (mtMSI), in order to clarify its biological role in GC.

AB - Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive microsatellite sequences during replication of DNA. Aberrant methylation is related to microsatellite instability (MSI) by the silencing of the hMLH1 gene. The aim of this study is to investigate a possible relationship between the RUNX3 promoter methylation, nuclear microsatellite instability (nMSI) and mitochondrial microsatellite instability (mtMSI), in order to clarify its biological role in GC.

UR - http://hdl.handle.net/10447/15817

M3 - Article

SN - 0923-7534

VL - 18 Suppl 6

SP - 103

EP - 109

JO - Annals of Oncology

JF - Annals of Oncology

ER -