Aberrant methylation within RUNX3 CpG island associated with the nuclear andmitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.

Risultato della ricerca: Article

18 Citazioni (Scopus)

Abstract

Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive microsatellite sequences during replication of DNA. Aberrant methylation is related to microsatellite instability (MSI) by the silencing of the hMLH1 gene. The aim of this study is to investigate a possible relationship between the RUNX3 promoter methylation, nuclear microsatellite instability (nMSI) and mitochondrial microsatellite instability (mtMSI), in order to clarify its biological role in GC.
Lingua originaleEnglish
pagine (da-a)103-109
RivistaAnnals of Oncology
Volume18 Suppl 6
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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