Aberrant gene expression profiles in Mediterranean sea urchin reproductive tissues after metal exposures

Marco Torri, Salvatore Costa, Marcello Tagliavia, Girolama Biondo, Marilena Vita Di Natale, Maria Antonietta Ragusa, Calogera Monastero, Girolama Biondo, Aldo Nicosia, Tiziana Masullo, Marco Torri, Carmelo Bennici, Marilena Di Natale, Calogera Monastero, Marcello Tagliavia, Angela Cuttitta, Aldo Nicosia, Angela Cuttitta

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Marine organisms are simultaneously exposed to numerous pollutants, among which metals probably represent the most abundant in marine environments. In order to evaluate the effects of metal exposure at molecular level in reproductive tissues, we profiled the sea urchin transcriptional response after non-lethal exposures using pathway-focused mRNA expression analyses. Herein, we show that exposures to relatively high concentrations of both essential and toxic metals hugely affected the gonadic expression of several genes involved in stress-response, detoxification, transcriptional and post-transcriptional regulation, without significant changes in gonadosomatic indices. Even though treatments did not result in reproductive tissues visible alterations, metal exposures negatively affected the main mechanisms of stress-response, detoxification and survival of adult P. lividus. Additionally, transcriptional changes observed in P. lividus gonads may cause altered gametogenesis and maintenance of heritable aberrant epigenetic effects. This study leads to the conclusion that exposures to metals, as usually occurs in polluted coastal areas, may affect sea urchin gametogenesis, thus supporting the hypothesis that parental exposure to environmental stressors affects the phenotype of the offspring.
Lingua originaleEnglish
pagine (da-a)48-58
Numero di pagine11
RivistaDefault journal
Volume216
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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Aberrant gene expression profiles in Mediterranean sea urchin reproductive tissues after metal exposures. / Torri, Marco; Costa, Salvatore; Tagliavia, Marcello; Biondo, Girolama; Di Natale, Marilena Vita; Ragusa, Maria Antonietta; Monastero, Calogera; Biondo, Girolama; Nicosia, Aldo; Masullo, Tiziana; Torri, Marco; Bennici, Carmelo; Di Natale, Marilena; Monastero, Calogera; Tagliavia, Marcello; Cuttitta, Angela; Nicosia, Aldo; Cuttitta, Angela.

In: Default journal, Vol. 216, 2019, pag. 48-58.

Risultato della ricerca: Article

Torri, M, Costa, S, Tagliavia, M, Biondo, G, Di Natale, MV, Ragusa, MA, Monastero, C, Biondo, G, Nicosia, A, Masullo, T, Torri, M, Bennici, C, Di Natale, M, Monastero, C, Tagliavia, M, Cuttitta, A, Nicosia, A & Cuttitta, A 2019, 'Aberrant gene expression profiles in Mediterranean sea urchin reproductive tissues after metal exposures', Default journal, vol. 216, pagg. 48-58.
Torri, Marco ; Costa, Salvatore ; Tagliavia, Marcello ; Biondo, Girolama ; Di Natale, Marilena Vita ; Ragusa, Maria Antonietta ; Monastero, Calogera ; Biondo, Girolama ; Nicosia, Aldo ; Masullo, Tiziana ; Torri, Marco ; Bennici, Carmelo ; Di Natale, Marilena ; Monastero, Calogera ; Tagliavia, Marcello ; Cuttitta, Angela ; Nicosia, Aldo ; Cuttitta, Angela. / Aberrant gene expression profiles in Mediterranean sea urchin reproductive tissues after metal exposures. In: Default journal. 2019 ; Vol. 216. pagg. 48-58.
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abstract = "Marine organisms are simultaneously exposed to numerous pollutants, among which metals probably represent the most abundant in marine environments. In order to evaluate the effects of metal exposure at molecular level in reproductive tissues, we profiled the sea urchin transcriptional response after non-lethal exposures using pathway-focused mRNA expression analyses. Herein, we show that exposures to relatively high concentrations of both essential and toxic metals hugely affected the gonadic expression of several genes involved in stress-response, detoxification, transcriptional and post-transcriptional regulation, without significant changes in gonadosomatic indices. Even though treatments did not result in reproductive tissues visible alterations, metal exposures negatively affected the main mechanisms of stress-response, detoxification and survival of adult P. lividus. Additionally, transcriptional changes observed in P. lividus gonads may cause altered gametogenesis and maintenance of heritable aberrant epigenetic effects. This study leads to the conclusion that exposures to metals, as usually occurs in polluted coastal areas, may affect sea urchin gametogenesis, thus supporting the hypothesis that parental exposure to environmental stressors affects the phenotype of the offspring.",
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T1 - Aberrant gene expression profiles in Mediterranean sea urchin reproductive tissues after metal exposures

AU - Torri, Marco

AU - Costa, Salvatore

AU - Tagliavia, Marcello

AU - Biondo, Girolama

AU - Di Natale, Marilena Vita

AU - Ragusa, Maria Antonietta

AU - Monastero, Calogera

AU - Biondo, Girolama

AU - Nicosia, Aldo

AU - Masullo, Tiziana

AU - Torri, Marco

AU - Bennici, Carmelo

AU - Di Natale, Marilena

AU - Monastero, Calogera

AU - Tagliavia, Marcello

AU - Cuttitta, Angela

AU - Nicosia, Aldo

AU - Cuttitta, Angela

PY - 2019

Y1 - 2019

N2 - Marine organisms are simultaneously exposed to numerous pollutants, among which metals probably represent the most abundant in marine environments. In order to evaluate the effects of metal exposure at molecular level in reproductive tissues, we profiled the sea urchin transcriptional response after non-lethal exposures using pathway-focused mRNA expression analyses. Herein, we show that exposures to relatively high concentrations of both essential and toxic metals hugely affected the gonadic expression of several genes involved in stress-response, detoxification, transcriptional and post-transcriptional regulation, without significant changes in gonadosomatic indices. Even though treatments did not result in reproductive tissues visible alterations, metal exposures negatively affected the main mechanisms of stress-response, detoxification and survival of adult P. lividus. Additionally, transcriptional changes observed in P. lividus gonads may cause altered gametogenesis and maintenance of heritable aberrant epigenetic effects. This study leads to the conclusion that exposures to metals, as usually occurs in polluted coastal areas, may affect sea urchin gametogenesis, thus supporting the hypothesis that parental exposure to environmental stressors affects the phenotype of the offspring.

AB - Marine organisms are simultaneously exposed to numerous pollutants, among which metals probably represent the most abundant in marine environments. In order to evaluate the effects of metal exposure at molecular level in reproductive tissues, we profiled the sea urchin transcriptional response after non-lethal exposures using pathway-focused mRNA expression analyses. Herein, we show that exposures to relatively high concentrations of both essential and toxic metals hugely affected the gonadic expression of several genes involved in stress-response, detoxification, transcriptional and post-transcriptional regulation, without significant changes in gonadosomatic indices. Even though treatments did not result in reproductive tissues visible alterations, metal exposures negatively affected the main mechanisms of stress-response, detoxification and survival of adult P. lividus. Additionally, transcriptional changes observed in P. lividus gonads may cause altered gametogenesis and maintenance of heritable aberrant epigenetic effects. This study leads to the conclusion that exposures to metals, as usually occurs in polluted coastal areas, may affect sea urchin gametogenesis, thus supporting the hypothesis that parental exposure to environmental stressors affects the phenotype of the offspring.

UR - http://hdl.handle.net/10447/348631

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