A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

Giuseppina Colonna Romano, Domenico Lio, Calogera Pisano, Carmela Rita Balistreri, Silvio Buffa, Giuseppe Mazzesi, Antonino G.M. Marullo, Giacomo Frati, Ernesto Greco, Giovanni Ruvolo, Sebastiano Sciarretta, Elena Cavarretta, Calogera Pisano, Silvia Palmerio, Sonia Schiavon

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL-17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27-), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD-CD27+), and double-negative B cells (DN) (IgD-CD27-). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaOxidative Medicine and Cellular Longevity
Volume2018
Stato di pubblicazionePublished - 2018

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Thoracic Aortic Aneurysm
Immunoglobulin D
Tricuspid Valve
B-Lymphocyte Subsets
B-Lymphocytes
Aortic Valve
Mitral Valve
Cells
Lymphocytes
T-Lymphocyte Subsets
Data storage equipment
Natural Killer T-Cells
T-cells
Interleukin-17
Vascular Diseases
Bicuspid Aortic Valve
Association reactions
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Ageing

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A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status? / Colonna Romano, Giuseppina; Lio, Domenico; Pisano, Calogera; Balistreri, Carmela Rita; Buffa, Silvio; Mazzesi, Giuseppe; Marullo, Antonino G.M.; Frati, Giacomo; Greco, Ernesto; Ruvolo, Giovanni; Sciarretta, Sebastiano; Cavarretta, Elena; Pisano, Calogera; Palmerio, Silvia; Schiavon, Sonia.

In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 2018, pag. -.

Risultato della ricerca: Article

Colonna Romano, G, Lio, D, Pisano, C, Balistreri, CR, Buffa, S, Mazzesi, G, Marullo, AGM, Frati, G, Greco, E, Ruvolo, G, Sciarretta, S, Cavarretta, E, Pisano, C, Palmerio, S & Schiavon, S 2018, 'A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?', Oxidative Medicine and Cellular Longevity, vol. 2018, pagg. -.
Colonna Romano, Giuseppina ; Lio, Domenico ; Pisano, Calogera ; Balistreri, Carmela Rita ; Buffa, Silvio ; Mazzesi, Giuseppe ; Marullo, Antonino G.M. ; Frati, Giacomo ; Greco, Ernesto ; Ruvolo, Giovanni ; Sciarretta, Sebastiano ; Cavarretta, Elena ; Pisano, Calogera ; Palmerio, Silvia ; Schiavon, Sonia. / A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018. pagg. -.
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title = "A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?",
abstract = "Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL-17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, na{\"i}ve B cells (IgD+CD27-), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD-CD27+), and double-negative B cells (DN) (IgD-CD27-). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.",
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T1 - A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

AU - Colonna Romano, Giuseppina

AU - Lio, Domenico

AU - Pisano, Calogera

AU - Balistreri, Carmela Rita

AU - Buffa, Silvio

AU - Mazzesi, Giuseppe

AU - Marullo, Antonino G.M.

AU - Frati, Giacomo

AU - Greco, Ernesto

AU - Ruvolo, Giovanni

AU - Sciarretta, Sebastiano

AU - Cavarretta, Elena

AU - Pisano, Calogera

AU - Palmerio, Silvia

AU - Schiavon, Sonia

PY - 2018

Y1 - 2018

N2 - Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL-17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27-), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD-CD27+), and double-negative B cells (DN) (IgD-CD27-). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.

AB - Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL-17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27-), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD-CD27+), and double-negative B cells (DN) (IgD-CD27-). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.

UR - http://hdl.handle.net/10447/290251

M3 - Article

VL - 2018

SP - -

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

SN - 1942-0900

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