A "systems medicine" approach to the study of non-alcoholic fatty liver disease

Salvatore Petta, Ester Vanni, Anna Prinster, Loreta Kondili, Barbara Coco, Elisabetta Bugianesi, Giovanni Targher, Luca Valenti, Luca Miele, Silvia Fargion, Amedeo Lonardo, Stefano Taddei, Federico Alessandro, Valerio Nobili, Ele Ferrannini, Fabio Nascimbeni, Marcello Mancini, Maurizia Rossana Brunetto, Carmela Loguercio, Ferruccio Bonino & 7 others Fabio Marra, Stefano Vella, Stefano Bellentani, Antonio Grieco, Gianluca Svegliati Baroni, Dante Romagnoli, Stefano Ballestri

Risultato della ricerca: Article

36 Citazioni (Scopus)

Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.
Lingua originaleEnglish
pagine (da-a)333-342
Numero di pagine10
RivistaDigestive and Liver Disease
Volume48
Stato di pubblicazionePublished - 2015

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Fatty Liver
Systems Analysis
Translational Medical Research
Systems Biology
Disease Susceptibility
Metabolic Diseases
Disease Progression
Non-alcoholic Fatty Liver Disease
Liver Diseases
Clinical Trials
Pathology
Phenotype
Population

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cita questo

Petta, S., Vanni, E., Prinster, A., Kondili, L., Coco, B., Bugianesi, E., ... Ballestri, S. (2015). A "systems medicine" approach to the study of non-alcoholic fatty liver disease. Digestive and Liver Disease, 48, 333-342.

A "systems medicine" approach to the study of non-alcoholic fatty liver disease. / Petta, Salvatore; Vanni, Ester; Prinster, Anna; Kondili, Loreta; Coco, Barbara; Bugianesi, Elisabetta; Targher, Giovanni; Valenti, Luca; Miele, Luca; Fargion, Silvia; Lonardo, Amedeo; Taddei, Stefano; Alessandro, Federico; Nobili, Valerio; Ferrannini, Ele; Nascimbeni, Fabio; Mancini, Marcello; Brunetto, Maurizia Rossana; Loguercio, Carmela; Bonino, Ferruccio; Marra, Fabio; Vella, Stefano; Bellentani, Stefano; Grieco, Antonio; Baroni, Gianluca Svegliati; Romagnoli, Dante; Ballestri, Stefano.

In: Digestive and Liver Disease, Vol. 48, 2015, pag. 333-342.

Risultato della ricerca: Article

Petta, S, Vanni, E, Prinster, A, Kondili, L, Coco, B, Bugianesi, E, Targher, G, Valenti, L, Miele, L, Fargion, S, Lonardo, A, Taddei, S, Alessandro, F, Nobili, V, Ferrannini, E, Nascimbeni, F, Mancini, M, Brunetto, MR, Loguercio, C, Bonino, F, Marra, F, Vella, S, Bellentani, S, Grieco, A, Baroni, GS, Romagnoli, D & Ballestri, S 2015, 'A "systems medicine" approach to the study of non-alcoholic fatty liver disease', Digestive and Liver Disease, vol. 48, pagg. 333-342.
Petta S, Vanni E, Prinster A, Kondili L, Coco B, Bugianesi E e altri. A "systems medicine" approach to the study of non-alcoholic fatty liver disease. Digestive and Liver Disease. 2015;48:333-342.
Petta, Salvatore ; Vanni, Ester ; Prinster, Anna ; Kondili, Loreta ; Coco, Barbara ; Bugianesi, Elisabetta ; Targher, Giovanni ; Valenti, Luca ; Miele, Luca ; Fargion, Silvia ; Lonardo, Amedeo ; Taddei, Stefano ; Alessandro, Federico ; Nobili, Valerio ; Ferrannini, Ele ; Nascimbeni, Fabio ; Mancini, Marcello ; Brunetto, Maurizia Rossana ; Loguercio, Carmela ; Bonino, Ferruccio ; Marra, Fabio ; Vella, Stefano ; Bellentani, Stefano ; Grieco, Antonio ; Baroni, Gianluca Svegliati ; Romagnoli, Dante ; Ballestri, Stefano. / A "systems medicine" approach to the study of non-alcoholic fatty liver disease. In: Digestive and Liver Disease. 2015 ; Vol. 48. pagg. 333-342.
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AU - Vanni, Ester

AU - Prinster, Anna

AU - Kondili, Loreta

AU - Coco, Barbara

AU - Bugianesi, Elisabetta

AU - Targher, Giovanni

AU - Valenti, Luca

AU - Miele, Luca

AU - Fargion, Silvia

AU - Lonardo, Amedeo

AU - Taddei, Stefano

AU - Alessandro, Federico

AU - Nobili, Valerio

AU - Ferrannini, Ele

AU - Nascimbeni, Fabio

AU - Mancini, Marcello

AU - Brunetto, Maurizia Rossana

AU - Loguercio, Carmela

AU - Bonino, Ferruccio

AU - Marra, Fabio

AU - Vella, Stefano

AU - Bellentani, Stefano

AU - Grieco, Antonio

AU - Baroni, Gianluca Svegliati

AU - Romagnoli, Dante

AU - Ballestri, Stefano

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