A "systems medicine" approach to the study of non-alcoholic fatty liver disease

Salvatore Petta, Valerio Nobili, Ele Ferrannini, Marcello Mancini, Maurizia Rossana Brunetto, Carmela Loguercio, Ferruccio Bonino, Fabio Marra, Stefano Vella, Stefano Bellentani, Antonio Grieco, Gianluca Svegliati Baroni, Dante Romagnoli, Fabio Nascimbeni, Stefano Ballestri, Ester Vanni, Anna Prinster, Loreta Kondili, Barbara Coco, Elisabetta BugianesiGiovanni Targher, Luca Valenti, Luca Miele, Silvia Fargion, Amedeo Lonardo, Stefano Taddei, Federico Alessandro

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Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.
Lingua originaleEnglish
pagine (da-a)333-342
Numero di pagine10
RivistaDigestive and Liver Disease
Volume48
Stato di pubblicazionePublished - 2016

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Petta, S., Nobili, V., Ferrannini, E., Mancini, M., Brunetto, M. R., Loguercio, C., Bonino, F., Marra, F., Vella, S., Bellentani, S., Grieco, A., Baroni, G. S., Romagnoli, D., Nascimbeni, F., Ballestri, S., Vanni, E., Prinster, A., Kondili, L., Coco, B., ... Alessandro, F. (2016). A "systems medicine" approach to the study of non-alcoholic fatty liver disease. Digestive and Liver Disease, 48, 333-342.