Abstract
Mild cognitive impairment (MCI) is a clinical concept proposed as an intermediate state between normal aging and
dementia. This condition has multiple heterogeneous sources, including clinical presentation, etiology, and prognosis. Recently,
the prevalence and associated features of neuropsychiatric symptoms (NPS) in MCI have been described. We systematically
searched the PubMed database (last accessed on August 31, 2008) for articles on NPS in MCI. Included articles used strict
selection criteria, and outcome variables were extracted in duplicate; of the 27 articles included, 14 (52%) used prospective
cohorts. The global prevalence of NPS in MCI ranged from 35% to 85%. The most common behavioral symptoms were
depression, anxiety, and irritability. Hospital-based samples reported a higher global prevalence of NPS than population-based
studies; this discrepancy probably reflected differences in demographics, study setting, MCI diagnostic criteria, and behavioral
instruments used. Prospective studies showed that NPS, particularly depression, may represent risk factors for MCI or predictors
for the conversion of MCI to Alzheimer’s disease (AD). NPS are very prevalent in subjects with MCI, displaying a similar pattern
of symptoms compared to dementia and AD. Large cohort studies using standardized MCI criteria and behavioral instruments
are required to evaluate the prognostic role of NPS in MCI.
Lingua originale | English |
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pagine (da-a) | 11-30 |
Numero di pagine | 20 |
Rivista | Journal of Alzheimer's Disease |
Volume | 2009-06-19 |
Stato di pubblicazione | Published - 2009 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.3200.3203???
- ???subjectarea.asjc.2700.2738???
- ???subjectarea.asjc.2700.2717???