A study of the human rod and cone electroretinogram a-wave component

Maria Brai, Rosita Maria Luisa Barraco, Dominique Persano Adorno, Persano Adorno, Bellomonte, Barraco, Brai, Leonardo Bellomonte

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8 Citazioni (Scopus)


The study of the electrical response of the retina to a luminousstimulus is one of the main fields of research in ocular electrophysiology. Thefeatures of the first component (a-wave) of the retinal response reflect thefunctional integrity of the two populations of photoreceptors: rods and cones. Wefit the a-wave for pathological subjects with functions that account for possiblemechanisms governing the kinetics of the photoreceptors. The paper extends aprevious analysis, carried out for normal subjects, in which both populations areactive, to patients affected by two particular diseases that reduce the workingpopulations to only one. The pathologies investigated are Achromatopsia, acone disease, and Congenital Stationary Night Blindness, a rod problem. Wepresent evidence that the analysis of a pathological a-wave can be employed toquantitatively measure either cone or rod activities and to test hypotheses abouttheir responses. The results show that the photoreceptoral responses differ in thetwo cases and functions implying a different number of photocascade stages arenecessary to achieve a correct modeling of the early phototransduction process.Numerical values of the parameters characterizing the best-fit functions are givenand discussed.
Lingua originaleEnglish
Numero di pagine11
RivistaJournal of Statistical Mechanics: Theory and Experiment
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2600.2613???
  • ???subjectarea.asjc.1800.1804???


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