A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

Giuseppe Badalamenti, Antonio Russo, Edoardo Botteri, Francesca Spada, Nicola Fazio, Antonio Ungaro, Filippo De Marinis, Eleonora Pisa, Nicole Romentz, Spaggiari Spaggiari, Marta Peri, Marta Peri, Chiara Maria Grana, Roberto Gasparri

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection. Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. P value descriptive data, uni- and multi-variate survival analysis were generated for all variables. Results: With a median follow-up of 53 [9-215] months, 61 patients with metachronous and 47 with synchronous metastases were analysed. The most common tool of first recurrence detection was computed tomography. Liver (67%), lymph node (25%), bone (22%) and lung (16%) were the most common sites of relapse. Median time to recurrence was 5 years. Median overall survival (OS) was 72 months for the whole population, with no significant difference between patients with synchronous and metachronous metastases. Age, bone metastases, liver metastases and Ki-67 as a continuous variable all significantly correlated with prognosis at the multivariate analysis. Conclusions: This is one of the largest, single-centre, series of metastatic bpNETs. Among patients with metachronous metastases the pattern of recurrences was heterogeneous as were the follow-up exams used to detect them. The results of our analysis may represent solid bases for designing prospective clinical trials in homogeneous settings of bpNETs.
Lingua originaleEnglish
pagine (da-a)3928-3939
Numero di pagine12
RivistaJournal of Thoracic Disease
Volume10
Stato di pubblicazionePublished - 2018

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Neuroendocrine Tumors
Neoplasm Metastasis
Lung
Recurrence
Bone and Bones
Liver
Survival Analysis
Disease Management
Multivariate Analysis
Lymph Nodes
Tomography
Demography
Clinical Trials
Pathology
Survival
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cita questo

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors. / Badalamenti, Giuseppe; Russo, Antonio; Botteri, Edoardo; Spada, Francesca; Fazio, Nicola; Ungaro, Antonio; Marinis, Filippo De; Pisa, Eleonora; Romentz, Nicole; Spaggiari, Spaggiari; Peri, Marta; Peri, Marta; Grana, Chiara Maria; Gasparri, Roberto.

In: Journal of Thoracic Disease, Vol. 10, 2018, pag. 3928-3939.

Risultato della ricerca: Article

Badalamenti, G, Russo, A, Botteri, E, Spada, F, Fazio, N, Ungaro, A, Marinis, FD, Pisa, E, Romentz, N, Spaggiari, S, Peri, M, Peri, M, Grana, CM & Gasparri, R 2018, 'A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors', Journal of Thoracic Disease, vol. 10, pagg. 3928-3939.
Badalamenti, Giuseppe ; Russo, Antonio ; Botteri, Edoardo ; Spada, Francesca ; Fazio, Nicola ; Ungaro, Antonio ; Marinis, Filippo De ; Pisa, Eleonora ; Romentz, Nicole ; Spaggiari, Spaggiari ; Peri, Marta ; Peri, Marta ; Grana, Chiara Maria ; Gasparri, Roberto. / A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors. In: Journal of Thoracic Disease. 2018 ; Vol. 10. pagg. 3928-3939.
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title = "A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors",
abstract = "Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection. Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. P value descriptive data, uni- and multi-variate survival analysis were generated for all variables. Results: With a median follow-up of 53 [9-215] months, 61 patients with metachronous and 47 with synchronous metastases were analysed. The most common tool of first recurrence detection was computed tomography. Liver (67{\%}), lymph node (25{\%}), bone (22{\%}) and lung (16{\%}) were the most common sites of relapse. Median time to recurrence was 5 years. Median overall survival (OS) was 72 months for the whole population, with no significant difference between patients with synchronous and metachronous metastases. Age, bone metastases, liver metastases and Ki-67 as a continuous variable all significantly correlated with prognosis at the multivariate analysis. Conclusions: This is one of the largest, single-centre, series of metastatic bpNETs. Among patients with metachronous metastases the pattern of recurrences was heterogeneous as were the follow-up exams used to detect them. The results of our analysis may represent solid bases for designing prospective clinical trials in homogeneous settings of bpNETs.",
author = "Giuseppe Badalamenti and Antonio Russo and Edoardo Botteri and Francesca Spada and Nicola Fazio and Antonio Ungaro and Marinis, {Filippo De} and Eleonora Pisa and Nicole Romentz and Spaggiari Spaggiari and Marta Peri and Marta Peri and Grana, {Chiara Maria} and Roberto Gasparri",
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TY - JOUR

T1 - A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors

AU - Badalamenti, Giuseppe

AU - Russo, Antonio

AU - Botteri, Edoardo

AU - Spada, Francesca

AU - Fazio, Nicola

AU - Ungaro, Antonio

AU - Marinis, Filippo De

AU - Pisa, Eleonora

AU - Romentz, Nicole

AU - Spaggiari, Spaggiari

AU - Peri, Marta

AU - Peri, Marta

AU - Grana, Chiara Maria

AU - Gasparri, Roberto

PY - 2018

Y1 - 2018

N2 - Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection. Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. P value descriptive data, uni- and multi-variate survival analysis were generated for all variables. Results: With a median follow-up of 53 [9-215] months, 61 patients with metachronous and 47 with synchronous metastases were analysed. The most common tool of first recurrence detection was computed tomography. Liver (67%), lymph node (25%), bone (22%) and lung (16%) were the most common sites of relapse. Median time to recurrence was 5 years. Median overall survival (OS) was 72 months for the whole population, with no significant difference between patients with synchronous and metachronous metastases. Age, bone metastases, liver metastases and Ki-67 as a continuous variable all significantly correlated with prognosis at the multivariate analysis. Conclusions: This is one of the largest, single-centre, series of metastatic bpNETs. Among patients with metachronous metastases the pattern of recurrences was heterogeneous as were the follow-up exams used to detect them. The results of our analysis may represent solid bases for designing prospective clinical trials in homogeneous settings of bpNETs.

AB - Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection. Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. P value descriptive data, uni- and multi-variate survival analysis were generated for all variables. Results: With a median follow-up of 53 [9-215] months, 61 patients with metachronous and 47 with synchronous metastases were analysed. The most common tool of first recurrence detection was computed tomography. Liver (67%), lymph node (25%), bone (22%) and lung (16%) were the most common sites of relapse. Median time to recurrence was 5 years. Median overall survival (OS) was 72 months for the whole population, with no significant difference between patients with synchronous and metachronous metastases. Age, bone metastases, liver metastases and Ki-67 as a continuous variable all significantly correlated with prognosis at the multivariate analysis. Conclusions: This is one of the largest, single-centre, series of metastatic bpNETs. Among patients with metachronous metastases the pattern of recurrences was heterogeneous as were the follow-up exams used to detect them. The results of our analysis may represent solid bases for designing prospective clinical trials in homogeneous settings of bpNETs.

UR - http://hdl.handle.net/10447/295518

UR - http://jtd.amegroups.com/article/download/22671/pdf

M3 - Article

VL - 10

SP - 3928

EP - 3939

JO - Journal of Thoracic Disease

JF - Journal of Thoracic Disease

SN - 2072-1439

ER -