A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

Giovanni Corsello, Alessandra Santoro, Maurizio Aricò, Antonino Trizzino, Sonia Cannella

Risultato della ricerca: Article

56 Citazioni (Scopus)

Abstract

We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.
Lingua originaleEnglish
pagine (da-a)697-698
Numero di pagine2
RivistaHaematologica
Volume90
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Hematology

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