A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding

Emanuele Sinagra; null Mazzuoli; null Lamboglia; Mauro Manno; Raffaele Manta; Sergio Peralta; Salvatore Camilleri; null De Matthaeis; Alessandro Natali; null Caliendo; Leonardo Tammaro; null Occhipinti; Emanuele Sinagra; null Sturniolo; null Antonini; Cesare Hassan; null Pallotta; Luigi Caserta; null Vitale; null Lauri; Roberto Vassallo; null Testai; null Cervellin; null Lauri; Giacomo Carlo Sturniolo; null Peccianti; null D'Angelo; Elisabetta Riccio; null Spotti; null De Matthaeis; null Kohn; null Costa; null De Fanis; null Biagini; null Di Bella; null Colucci; null Lauri; null Azzurro; null De Bona; null Campaioli; null De Boni; null Ridolfi; null Occhigrossi; null Ferronato; Andrea Anderloni; Luigi Montalbano; null Brunelli; null Virgilio; null Virgilio; Giampiero Macarri; null Pozzato; null Balzano; Maria Carla Di Paolo; null Conigliaro; null Guglielmi; null Di Bella; Maurizio Ventrucci; null Colucci; Giorgio Frosini; Angelo Zullo; null Milani; null Adamo; Antonio Craxì; null Conio; Andrea Buda; null Tesi; null Marin; null Parodi; null D'Amico; null Marini; Giuseppe Scarpulla

A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding

Emanuele Sinagra, Mazzuoli, Lamboglia, Mauro Manno, Raffaele Manta, Sergio Peralta, Salvatore Camilleri, De Matthaeis, Alessandro Natali, Caliendo, Leonardo Tammaro, Occhipinti, Emanuele Sinagra, Sturniolo, Antonini, Cesare Hassan, Pallotta, Luigi Caserta, Vitale, LauriRoberto Vassallo, Testai, Cervellin, Lauri, Giacomo Carlo Sturniolo, Peccianti, D'Angelo, Elisabetta Riccio, Spotti, De Matthaeis, Kohn, Costa, De Fanis, Biagini, Di Bella, Colucci, Lauri, Azzurro, De Bona, Campaioli, De Boni, Ridolfi, Occhigrossi, Ferronato, Andrea Anderloni, Luigi Montalbano, Brunelli, Virgilio, Virgilio, Giampiero Macarri, Pozzato, Balzano, Maria Carla Di Paolo, Conigliaro, Guglielmi, Di Bella, Maurizio Ventrucci, Colucci, Giorgio Frosini, Angelo Zullo, Milani, Adamo, Antonio Craxì, Conio, Andrea Buda, Tesi, Marin, Parodi, D'Amico, Marini, Giuseppe Scarpulla

Risultato della ricerca: Article › peer review

16 Citazioni (Scopus)

Abstract

Background: Pre-endoscopic triage of patients who require an early upper endoscopy can improve management of patients with non-variceal upper gastrointestinal bleeding. Aims: To validate a new simplified clinical score (T-score) to assess the need of an early upper endoscopy in non variceal bleeding patients. Secondary outcomes were re-bleeding rate, 30-day bleeding-related mortality. Methods: In this prospective, multicentre study patients with bleeding who underwent upper endoscopy were enrolled. The accuracy for high risk endoscopic stigmata of the T-score was compared with that of the Glasgow Blatchford risk score. Results: Overall, 602 patients underwent early upper endoscopy, and 472 presented with non-variceal bleeding. High risk endoscopic stigmata were detected in 145 (30.7%) cases. T-score sensitivity and specificity for high risk endoscopic stigmata and bleeding-related mortality was 96% and 30%, and 80% and 71%, respectively. No statistically difference in predicting high risk endoscopic stigmata between T-score and Glasgow Blatchford risk score was observed (ROC curve: 0.72 vs. 0.69, p=0.11). The two scores were also similar in predicting re-bleeding (ROC curve: 0.64 vs. 0.63, p=0.4) and 30-day bleeding-related mortality (ROC curve: 0.78 vs. 0.76, p=0.3). Conclusions: The T-score appeared to predict high risk endoscopic stigmata, re-bleeding and mortality with similar accuracy to Glasgow Blatchford risk score. Such a score may be helpful for the prediction of high-risk patients who need a very early therapeutic endoscopy

Lingua originale	English
pagine (da-a)	783-787
Numero di pagine	5
Rivista	Digestive and Liver Disease
Volume	46
Stato di pubblicazione	Published - 2014

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Sinagra, E., Mazzuoli, Lamboglia, Manno, M., Manta, R., Peralta, S., Camilleri, S., De Matthaeis, Natali, A., Caliendo, Tammaro, L., Occhipinti, Sinagra, E., Sturniolo, Antonini, Hassan, C., Pallotta, Caserta, L., Vitale, ... Scarpulla, G. (2014). A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding. Digestive and Liver Disease, 46, 783-787.

Sinagra, E, Mazzuoli, Lamboglia, Manno, M, Manta, R, Peralta, S, Camilleri, S, De Matthaeis, Natali, A, Caliendo, Tammaro, L, Occhipinti, Sinagra, E, Sturniolo, Antonini, Hassan, C, Pallotta, Caserta, L, Vitale, Lauri, Vassallo, R, Testai, Cervellin, Lauri, Sturniolo, GC, Peccianti, D'Angelo, Riccio, E, Spotti, De Matthaeis, Kohn, Costa, De Fanis, Biagini, Di Bella, Colucci, Lauri, Azzurro, De Bona, Campaioli, De Boni, Ridolfi, Occhigrossi, Ferronato, Anderloni, A, Montalbano, L, Brunelli, Virgilio, Virgilio, Macarri, G, Pozzato, Balzano, Di Paolo, MC, Conigliaro, Guglielmi, Di Bella, Ventrucci, M, Colucci, Frosini, G, Zullo, A, Milani, Adamo, Craxì, A, Conio, Buda, A, Tesi, Marin, Parodi, D'Amico, Marini & Scarpulla, G 2014, 'A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding', Digestive and Liver Disease, vol. 46, pagg. 783-787.

@article{49867ed898ea45238ea3d776c1867802,

title = "A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding",

abstract = "Background: Pre-endoscopic triage of patients who require an early upper endoscopy can improve management of patients with non-variceal upper gastrointestinal bleeding. Aims: To validate a new simplified clinical score (T-score) to assess the need of an early upper endoscopy in non variceal bleeding patients. Secondary outcomes were re-bleeding rate, 30-day bleeding-related mortality. Methods: In this prospective, multicentre study patients with bleeding who underwent upper endoscopy were enrolled. The accuracy for high risk endoscopic stigmata of the T-score was compared with that of the Glasgow Blatchford risk score. Results: Overall, 602 patients underwent early upper endoscopy, and 472 presented with non-variceal bleeding. High risk endoscopic stigmata were detected in 145 (30.7%) cases. T-score sensitivity and specificity for high risk endoscopic stigmata and bleeding-related mortality was 96% and 30%, and 80% and 71%, respectively. No statistically difference in predicting high risk endoscopic stigmata between T-score and Glasgow Blatchford risk score was observed (ROC curve: 0.72 vs. 0.69, p=0.11). The two scores were also similar in predicting re-bleeding (ROC curve: 0.64 vs. 0.63, p=0.4) and 30-day bleeding-related mortality (ROC curve: 0.78 vs. 0.76, p=0.3). Conclusions: The T-score appeared to predict high risk endoscopic stigmata, re-bleeding and mortality with similar accuracy to Glasgow Blatchford risk score. Such a score may be helpful for the prediction of high-risk patients who need a very early therapeutic endoscopy",

author = "Emanuele Sinagra and Mazzuoli and Lamboglia and Mauro Manno and Raffaele Manta and Sergio Peralta and Salvatore Camilleri and {De Matthaeis} and Alessandro Natali and Caliendo and Leonardo Tammaro and Occhipinti and Emanuele Sinagra and Sturniolo and Antonini and Cesare Hassan and Pallotta and Luigi Caserta and Vitale and Lauri and Roberto Vassallo and Testai and Cervellin and Lauri and Sturniolo, {Giacomo Carlo} and Peccianti and D'Angelo and Elisabetta Riccio and Spotti and {De Matthaeis} and Kohn and Costa and {De Fanis} and Biagini and {Di Bella} and Colucci and Lauri and Azzurro and {De Bona} and Campaioli and {De Boni} and Ridolfi and Occhigrossi and Ferronato and Andrea Anderloni and Luigi Montalbano and Brunelli and Virgilio and Virgilio and Giampiero Macarri and Pozzato and Balzano and {Di Paolo}, {Maria Carla} and Conigliaro and Guglielmi and {Di Bella} and Maurizio Ventrucci and Colucci and Giorgio Frosini and Angelo Zullo and Milani and Adamo and Antonio Crax{\`i} and Conio and Andrea Buda and Tesi and Marin and Parodi and D'Amico and Marini and Giuseppe Scarpulla",

year = "2014",

language = "English",

volume = "46",

pages = "783--787",

journal = "Digestive and Liver Disease",

issn = "1590-8658",

publisher = "Elsevier",

}

TY - JOUR

T1 - A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding

AU - Sinagra, Emanuele

AU - Mazzuoli, null

AU - Lamboglia, null

AU - Manno, Mauro

AU - Manta, Raffaele

AU - Peralta, Sergio

AU - Camilleri, Salvatore

AU - De Matthaeis, null

AU - Natali, Alessandro

AU - Caliendo, null

AU - Tammaro, Leonardo

AU - Occhipinti, null

AU - Sinagra, Emanuele

AU - Sturniolo, null

AU - Antonini, null

AU - Hassan, Cesare

AU - Pallotta, null

AU - Caserta, Luigi

AU - Vitale, null

AU - Lauri, null

AU - Vassallo, Roberto

AU - Testai, null

AU - Cervellin, null

AU - Lauri, null

AU - Sturniolo, Giacomo Carlo

AU - Peccianti, null

AU - D'Angelo, null

AU - Riccio, Elisabetta

AU - Spotti, null

AU - De Matthaeis, null

AU - Kohn, null

AU - Costa, null

AU - De Fanis, null

AU - Biagini, null

AU - Di Bella, null

AU - Colucci, null

AU - Lauri, null

AU - Azzurro, null

AU - De Bona, null

AU - Campaioli, null

AU - De Boni, null

AU - Ridolfi, null

AU - Occhigrossi, null

AU - Ferronato, null

AU - Anderloni, Andrea

AU - Montalbano, Luigi

AU - Brunelli, null

AU - Virgilio, null

AU - Macarri, Giampiero

AU - Pozzato, null

AU - Balzano, null

AU - Di Paolo, Maria Carla

AU - Conigliaro, null

AU - Guglielmi, null

AU - Di Bella, null

AU - Ventrucci, Maurizio

AU - Colucci, null

AU - Frosini, Giorgio

AU - Zullo, Angelo

AU - Milani, null

AU - Adamo, null

AU - Craxì, Antonio

AU - Conio, null

AU - Buda, Andrea

AU - Tesi, null

AU - Marin, null

AU - Parodi, null

AU - D'Amico, null

AU - Marini, null

AU - Scarpulla, Giuseppe

PY - 2014

Y1 - 2014

N2 - Background: Pre-endoscopic triage of patients who require an early upper endoscopy can improve management of patients with non-variceal upper gastrointestinal bleeding. Aims: To validate a new simplified clinical score (T-score) to assess the need of an early upper endoscopy in non variceal bleeding patients. Secondary outcomes were re-bleeding rate, 30-day bleeding-related mortality. Methods: In this prospective, multicentre study patients with bleeding who underwent upper endoscopy were enrolled. The accuracy for high risk endoscopic stigmata of the T-score was compared with that of the Glasgow Blatchford risk score. Results: Overall, 602 patients underwent early upper endoscopy, and 472 presented with non-variceal bleeding. High risk endoscopic stigmata were detected in 145 (30.7%) cases. T-score sensitivity and specificity for high risk endoscopic stigmata and bleeding-related mortality was 96% and 30%, and 80% and 71%, respectively. No statistically difference in predicting high risk endoscopic stigmata between T-score and Glasgow Blatchford risk score was observed (ROC curve: 0.72 vs. 0.69, p=0.11). The two scores were also similar in predicting re-bleeding (ROC curve: 0.64 vs. 0.63, p=0.4) and 30-day bleeding-related mortality (ROC curve: 0.78 vs. 0.76, p=0.3). Conclusions: The T-score appeared to predict high risk endoscopic stigmata, re-bleeding and mortality with similar accuracy to Glasgow Blatchford risk score. Such a score may be helpful for the prediction of high-risk patients who need a very early therapeutic endoscopy

AB - Background: Pre-endoscopic triage of patients who require an early upper endoscopy can improve management of patients with non-variceal upper gastrointestinal bleeding. Aims: To validate a new simplified clinical score (T-score) to assess the need of an early upper endoscopy in non variceal bleeding patients. Secondary outcomes were re-bleeding rate, 30-day bleeding-related mortality. Methods: In this prospective, multicentre study patients with bleeding who underwent upper endoscopy were enrolled. The accuracy for high risk endoscopic stigmata of the T-score was compared with that of the Glasgow Blatchford risk score. Results: Overall, 602 patients underwent early upper endoscopy, and 472 presented with non-variceal bleeding. High risk endoscopic stigmata were detected in 145 (30.7%) cases. T-score sensitivity and specificity for high risk endoscopic stigmata and bleeding-related mortality was 96% and 30%, and 80% and 71%, respectively. No statistically difference in predicting high risk endoscopic stigmata between T-score and Glasgow Blatchford risk score was observed (ROC curve: 0.72 vs. 0.69, p=0.11). The two scores were also similar in predicting re-bleeding (ROC curve: 0.64 vs. 0.63, p=0.4) and 30-day bleeding-related mortality (ROC curve: 0.78 vs. 0.76, p=0.3). Conclusions: The T-score appeared to predict high risk endoscopic stigmata, re-bleeding and mortality with similar accuracy to Glasgow Blatchford risk score. Such a score may be helpful for the prediction of high-risk patients who need a very early therapeutic endoscopy

UR - http://hdl.handle.net/10447/141640

M3 - Article

SN - 1590-8658

VL - 46

SP - 783

EP - 787

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

ER -

A simplified clinical risk score predicts the need for early endoscopy in non-variceal upper gastrointestinal bleeding

Abstract

All Science Journal Classification (ASJC) codes

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