A recent portrait of bioactive triazoles

Risultato della ricerca: Articlepeer review

32 Citazioni (Scopus)


Scientists have extensively explored new synthetic routes in order to obtain 1,2,3- and 1,2,4-triazoles as theyrepresent a very interesting class of compounds due to their wide range of biological activities such as antitumor, antiinflammatory,analgesic, antifungal, antibacterial, antiviral, etc. This mini review reports the synthesis and the biologicalactivities of compounds containing a triazole moiety published since 2007. No attempt is made to provide a comprehensiveliterature overview, our aim is to highlight some more recent examples of synthetic biological active compounds. Inparticular, we focus on the applications of “click reactions” that allow the regioselective synthesis of 1,2,3 triazoles aswell as on bioactive 1,2,4 triazoles obtained by classic and improved synthetic methodologies. Moreover bioactivity ofglycoconjugated, and metal complexes with triazole as ligands are herein discussed, fused ring heterocycles have not beentaken into account. Where possible some comments on structure-activity relationships are referred.
Lingua originaleEnglish
pagine (da-a)208-242
Numero di pagine35
RivistaCurrent Bioactive Compounds
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

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