Abstract
A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 85-94 |
| Numero di pagine | 10 |
| Rivista | Arkivoc |
| Volume | VIII |
| Stato di pubblicazione | Published - 2009 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1600.1605???