A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs

Marco Tutone; Antonino Lauria; Anna Maria Almerico

A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs

Marco Tutone, Antonino Lauria, Anna Maria Almerico

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

9 Citazioni (Scopus)

Abstract

A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.

Lingua originale	English
pagine (da-a)	85-94
Numero di pagine	10
Rivista	Arkivoc
Volume	VIII
Stato di pubblicazione	Published - 2009

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs",

abstract = "A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.",

author = "Marco Tutone and Antonino Lauria and Almerico, {Anna Maria}",

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AU - Tutone, Marco

AU - Lauria, Antonino

AU - Almerico, Anna Maria

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N2 - A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.

AB - A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.

UR - http://hdl.handle.net/10447/45630

M3 - Article

VL - VIII

SP - 85

EP - 94

JO - Arkivoc

JF - Arkivoc

SN - 1551-7004

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