A prospective evaluation of the activity of human granulocyte-colony stimulating factor on the prevention of chemotherapy-related neutropenia in patients with advanced carcinoma

Nicolo' Gebbia, Vittorio Gebbia, Calogero Cipolla, Mario Latteri, Nicola Gebbia, Nicolò Borsellino, Vittorio Gebbia, Curto, Matteo Florena, Valenza, Cannata, Calogero Cipolla, Mario A. Latteri, Testa, Matteo Florena

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27 Citazioni (Scopus)

Abstract

After informed consent, 86 patients with advanced cancer undergoing potentially myelosuppressive cytotoxic chemotherapy were randomized to receive placebo or subcutaneous granulocyte - colony stimulating factor (G- CSF) 5 μg/Kg/day in order to prevent severe neutropenia and its related morbidity. The incidence of neutropenia (absolute neutrophil count <1, 000/mm3) was significantly reduced in patients receiving G-CSF than in controls (18% versus 42%; P <0.05). The duration of neutropenia was also shortened by the administration of G-CSF (4.8 versus 8.2 days; P <0.05). Therapy with G-CSF has also a positive impact on the dose-intensity of employed regimens. Patients treated with G-CSF showed oral fungal disease in 9% of cases, while control patients had a 21% incidence (NS). Patients treated with G-CSF received 91% of the programmed dose-intensity as compared to 71% of control patients (P <0.05). These data strengthen the clinical usefulness of G-CSF in the prevention of chemotherapy-related neutropenia, infections, and reduction in dose-intensity. Further studies are required to establish if the increase in dose-intensity allowed by G-CSF treatment may positively influence the outcome of cancer patients.
Lingua originaleEnglish
pagine (da-a)186-190
Numero di pagine5
RivistaJournal of Chemotherapy
Volume5
Stato di pubblicazionePublished - 1993

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3004???
  • ???subjectarea.asjc.2700.2736???
  • ???subjectarea.asjc.2700.2725???

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