A Pilot Study on Prostate Cancer Risk and Pro-Inflammatory Genotypes: Pathophysiologyand Therapeutic Implications

Calogero Caruso, Giuseppina Colonna Romano, Domenico Lio, Giuseppina Candore, Carmela Rita Balistreri, Giuseppe Carruba, Vitale Miceli, Ildegarda Campisi, Florinda Listi'

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33 Citazioni (Scopus)

Abstract

Host genetic factors are crucial risk determinants for many human cancers. In this framework, an interesting model isrepresented by prostate cancer (PC), which is featured by a complex pathophysiology with a strong genetic component. Multiple genesseem to influence PC risk and several single nucleotide polymorphisms (SNPs) of candidate genes modifying PC susceptibility have beenidentified. It is noteworthy the potential association of common SNPs in pro-inflammatory genes with PC risk, since chronicinflammation is assumed to play a key role in prostate carcinogenesis. With the aim to identify candidate genes as an experimental basisto develop new strategies for both prevention and treatment of PC, we have investigated the potential role of common SNPs of a genecluster (TLR4, TLR2, PTGS2 and 5-Lo), involved in innate and inflammatory response, in PC cases, age-matched controls andcentenarians from Sicily. Six SNPs were genotyped and their association with PC risk determined. Statistical analysis evidenced asignificant association of some pro-inflammatory gene SNPs with an increased risk of PC. Furthermore, significant differences wereobserved comparing the three groups in the combined presence of a “high responder” pro-inflammatory profile. Overall, the presentresults suggest the likely association of these SNPs and PC risk, clearly motivating the need of larger studies to confirm the role of thesegenes in PC development and/or progression.
Lingua originaleEnglish
pagine (da-a)718-724
Numero di pagine7
RivistaCURRENT PHARMACEUTICAL DESIGN
Volume16
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology
  • Drug Discovery

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