A one-pot method to enhance dissolution rate of low solubility drug moleculesusing dispersion polymerization in supercritical carbon dioxide

Tiziana Spano', Alessandro Galia, Onofrio Scialdone, Giuseppe Filardo, Tiziana Spanò, Onofrio Scialdone, Giuseppe Filardo, Alessandro Galia

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

The surfactant assisted polymerization of 1-vinyl-2-pyrrolidone in supercritical carbon dioxide in thepresence of Piroxicam, selected as a model of a low aqueous solubility drug, was studied in order toprepare in a single step a polymeric composite to enhance the rate of dissolution of the pharmaceuticalcompound. Reactive entrappingwas carried out at 65 ◦C in theP range 21–38MPa.Under proper operativeconditions we obtained the composite under the form of sub-micron spherical particles with relativelynarrowparticle size distribution. Drug loadings higher than 12% (w/w)were obtained andXRDand Ramanspectroscopy suggest that the anti-inflammatory agent is dispersed in the matrix with a non-crystallinestructure. The dissolution rate of the drug from the composites was significantly faster both than thatof the pure compound and of its physical mixture with the polymer. Collected results suggest that theproposed one-pot process can be used to prepare polymer based composites to increase bioavailabilityof low solubility drugs without utilization of toxic solvents and under mild temperature conditions.
Lingua originaleEnglish
pagine (da-a)60-69
Numero di pagine10
RivistaInternational Journal of Pharmaceutics
Volume377
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.3000.3003???

Fingerprint

Entra nei temi di ricerca di 'A one-pot method to enhance dissolution rate of low solubility drug moleculesusing dispersion polymerization in supercritical carbon dioxide'. Insieme formano una fingerprint unica.

Cita questo