A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia

Landi, A.; Alafaci, C.

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN has suggested a new possible mechanism for TN. The findings of this new mutation provide novel information that warrants further conclusive investigations.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine7
RivistaMolecular Medicine
Stato di pubblicazionePublished - 2016

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Trigeminal Neuralgia
Trigeminal Nerve
Sodium Channels
Valine
Neuralgia
Demyelinating Diseases
Synaptic Transmission
Methionine
Brain Stem
Head
Mutation

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A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia. / Landi, A.; Alafaci, C.

In: Molecular Medicine, 2016, pag. -.

Risultato della ricerca: Article

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AB - Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN has suggested a new possible mechanism for TN. The findings of this new mutation provide novel information that warrants further conclusive investigations.

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