A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-L-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

Simona Rubino, Girolamo Casella, Maria Assunta Girasolo, Luisa Tesoriere, Giampaolo Barone, Alessandro Attanzio, Riccardo Bonsignore, Giampaolo Barone, Piera Sabatino, Massimo L. Capobianco, Girolamo Casella

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12 Citazioni (Scopus)

Abstract

The triphenyltin(IV) compound with N-tert-butoxycarbonyl-L-ornithine (Boc-Orn-OH), [Ph3Sn(Boc-Orn-O)], was synthesized and characterized by elemental analysis, FT-IR, solution 1H, 13C and 119Sn NMR and ESI mass spectrometry. The organotin(IV) compound inhibited at very low micromolar concentrations the growth of human tumor cell lines HepG2 (hepatocarcinoma cells), MCF-7 (mammary cancer) and HCT116 (colorectal carcinoma) while it did not affect the viability of non-malignant human-derived hepatic cells Chang. The mechanism of the antiproliferative effect of Ph3Sn(Boc-Orn-O), investigated on human hepatoma HepG2 cells, was pro-apoptotic, being associated with externalization of plasma membrane phosphatidylserine, chromatin condensation or fragmentation and mitochondrial dysfunction as well as with increase of p53 levels.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaInorganica Chimica Acta
Volume456
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1600.1604???
  • ???subjectarea.asjc.2500.2505???

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