Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we comparedplasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases toplasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were stronglyand significantly associated with KS, after adjustment for age and smokingstatus. These and previous observations are consistent with a tumor-promotingrole for these cytokines, particularly CXCL10, but the small sample size andcase-control design preclude firm conclusions on KS risk or pathogenesis. Larger,well-designed prospective studies are needed to better assess the association of these markers with KS.
|Numero di pagine||4|
|Rivista||THE JOURNAL OF INFECTIOUS DISEASES|
|Stato di pubblicazione||Published - 2015|
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