A multiomics analysis of S100 protein family in breast cancer

Miriam Buttacavoli, Salvatore Feo, Patrizia Cancemi, Serena Bivona, Nadia Ninfa Albanese, Gianluca Di Cara, Ida Pucci-Minafra, Patrizia Cancemi, Salvatore Feo, Gianluca Di Cara, Nadia Ninfa Albanese

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

The S100 gene family is the largest subfamily of calcium binding proteins of EFhand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators. There is a growing interest in the S100 proteins and their relationships with different cancers because of their involvement in a variety of biological events closely related to tumorigenesis and cancer progression. However, the collective role and the possible coordination of this group of proteins, as well as the functional implications of their expression in breast cancer (BC) is still poorly known. We previously reported a large-scale proteomic investigation performed on BC patients for the screening of multiple forms of S100 proteins. Present study was aimed to assess the functional correlation between protein and gene expression patterns and the prognostic values of the S100 family members in BC. By using data mining, we showed that S100 members were collectively deregulated in BC, and their elevated expression levels were correlated with shorter survival and more aggressive phenotypes of BC (basal like, HER2 enriched, ER-negative and high grading). Moreover a multi-omics functional network analysis highlighted the regulatory effects of S100 members on several cellular pathways associated with cancer and cancer progression, expecially immune response and inflammation. Interestingly, for the first time, a pathway analysis was successfully applied on different omics data (transcriptomics and proteomics) revealing a good convergence between pathways affected by S100 in BC. Our data confirm S100 members as a promising panel of biomarkers for BC prognosis.
Lingua originaleEnglish
pagine (da-a)29064-29081
Numero di pagine18
RivistaOncotarget
Volume9
Stato di pubblicazionePublished - 2018

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S100 Proteins
Breast Neoplasms
Proteomics
Neoplasms
Calcium-Binding Proteins
Data Mining
Early Detection of Cancer
Carcinogenesis
Proteins
Biomarkers
Inflammation
Phenotype
Gene Expression
Survival
Genes

All Science Journal Classification (ASJC) codes

  • Oncology

Cita questo

Buttacavoli, M., Feo, S., Cancemi, P., Bivona, S., Albanese, N. N., Cara, G. D., ... Albanese, N. N. (2018). A multiomics analysis of S100 protein family in breast cancer. Oncotarget, 9, 29064-29081.

A multiomics analysis of S100 protein family in breast cancer. / Buttacavoli, Miriam; Feo, Salvatore; Cancemi, Patrizia; Bivona, Serena; Albanese, Nadia Ninfa; Cara, Gianluca Di; Pucci-Minafra, Ida; Cancemi, Patrizia; Feo, Salvatore; Di Cara, Gianluca; Albanese, Nadia Ninfa.

In: Oncotarget, Vol. 9, 2018, pag. 29064-29081.

Risultato della ricerca: Article

Buttacavoli, M, Feo, S, Cancemi, P, Bivona, S, Albanese, NN, Cara, GD, Pucci-Minafra, I, Cancemi, P, Feo, S, Di Cara, G & Albanese, NN 2018, 'A multiomics analysis of S100 protein family in breast cancer', Oncotarget, vol. 9, pagg. 29064-29081.
Buttacavoli, Miriam ; Feo, Salvatore ; Cancemi, Patrizia ; Bivona, Serena ; Albanese, Nadia Ninfa ; Cara, Gianluca Di ; Pucci-Minafra, Ida ; Cancemi, Patrizia ; Feo, Salvatore ; Di Cara, Gianluca ; Albanese, Nadia Ninfa. / A multiomics analysis of S100 protein family in breast cancer. In: Oncotarget. 2018 ; Vol. 9. pagg. 29064-29081.
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AU - Cara, Gianluca Di

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