A multicentric randomized study comparing two techniques of magnification assisted loop excision of high-grade cervical intraepithelial neoplasia: Video exoscopy and colposcopy

Vito Chiantera, Inka Drechsler, Anna Maria Dückelmann, Evrim Erdemoglu, Gerd Böhmer, Giuseppe F. Vercellino, Katharina Vasiljeva, Janine Richter, Al-Hakeem Malak, Achim Schneider, Vito Chiantera

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

Purpose: To compare loop excisions of cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) under video exoscopy, or colposcopic guidance, with respect to safety and effectiveness. Methods: Prospective multicentric randomized trial of 300 patients, undergoing loop excision for CIN 2+ either under video exoscopy (group A) or colposcope (group B) guidance. Intra- and post-operative complications, resection margins, and removed cervical volume in both groups were evaluated. Results: 19.3% of patients in video exoscopy group and 15.5% in colposcopy group (p = 0.67) had transformation zone (TZ) 3. 45/151 (29.8%) of group A patients and 48/149 (32.2%) of group B patients underwent top-hat procedure, i.e., one superficial excision followed by one deeper removal of the endocervical tissue (p = 0.74). There was no difference in intra- and post-operative complications in the two groups. Positive endocervical resection margins (R0) were 9.9% in video exoscopy group and 8.7% in colposcopy group, respectively. Unclear endocervical resection margins (Rx) were 2.0% in both groups. Mean total excised cervical volume was 1.20 cubic centimeter (cc 3) in group A, and 1.24 cc3 in group B, respectively. Recurrent disease occurred in 2.3% of patients at 6 months follow-up. Conclusion: Magnification assisted loop excision of CIN 2+ is equally effective and safe under colposcopic and video exoscopy guidance. The latter technique could potentially offer an alternative treatment of CIN 2+ lesions for doctors unfamiliar with colposcope. © Springer-Verlag 2013.
Lingua originaleEnglish
pagine (da-a)1301-1307
Numero di pagine7
RivistaArchives of Gynecology and Obstetrics
Volume289
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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