A Multicenter International Randomized Controlled Manikin Study on Different Protocols of Cardiopulmonary Resuscitation for Laypeople: The MANI-CPR Trial

Antonino Giarratano, Andrea Cortegiani, Marinella Pugliesi, Sandrine Dénéréaz, Ottavia Eleonora Ferraro, Andrea Cortegiani, Enrico Baldi, Daniele Bertaia, Enrico Contri, Paola Borrelli, Roman Burkart, Michael Terrapon, Christian Tami, Susi Boldarin, Daniel Lopez, Martina Paglino, Andrea Cortegiani, Chiara Barbati, Francesca Montalto, Marinella PugliesiPasquale Iozzo

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)


Background: Compression-only cardiopulmonary resuscitation (CPR) is a suggested technique for laypeople facing out-of-hospital cardiac arrest (OHCA). However, it is difficult performing high-quality CPR until emergency medical services arrival with this technique. We aimed to verify whether incorporating intentional interruptions of different frequency and duration increases laypeople's CPR quality during an 8-minute scenario compared with compression-only CPR.Methods: We performed a multicenter randomized manikin study selecting participants from 2154 consecutive laypeople who followed a basic life support/automatic external defibrillation course. People who achieved high-quality CPR in 1-minute test on a computerized manikin were asked to participate. Five hundred seventy-six were enrolled, and 59 were later excluded for technical reasons or incorrect test recording. Participants were randomized in an 8-minute OHCA scenario using 3 CPR protocols (30 compressions and 2-second pause, 30c2s; 50 compressions and 5-second pause, 50c5s; 100 compressions and 10-second pause, 100c10s) or compression-only technique. The main outcome was the percentage of chest compressions with adequate depth.Results: Five hundred seventeen participants were evaluated. There was a statistically significant difference regarding the percentage of compressions with correct depth among the groups (30c2s, 96%; 50c5s, 96%; 100c10s, 92%; compression only, 79%; P = 0.006). Post hoc comparison showed a significant difference for 30c2s (P = 0.023) and for 50c5s (P = 0.003) versus compression only. Regarding secondary outcome, there were a higher chest compression fraction in the compression-only group and a higher rate of pauses longer than 10 seconds in the 100c10s.Conclusions: In a simulated OHCA, 30c2s and 50c5s protocols were characterized by a higher rate of chest compressions with correct depth than compression only. This could have practical consequences in laypeople CPR training and recommendations.
Lingua originaleEnglish
Numero di pagine12
RivistaSimulation in Healthcare
VolumePublish Ahead of Print
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2701???
  • ???subjectarea.asjc.3300.3304???
  • ???subjectarea.asjc.2600.2611???


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