A headlight on liquid biopsies: a challenging tool for breast cancer management

Giuseppe Bronte, Antonina Cangemi, Viviana Bazan, Daniela Massihnia, Nadia Barraco, Alessandro Perez, Antonio Russo, Gianni Pantuso, Valentina Calo', Giuseppe Cicero, Marta Castiglia, Daniele Fanale, Florinda Di Piazza, Antonio Russo, Marta Castiglia, Antonina Cangemi, Nadia Barraco, Daniela Massihnia, Alessandro Perez, Giuseppe CiceroDaniele Fanale, Gianni Pantuso, Viviana Bazan, Valentina Calò, Sergio Rizzo, Giuseppe Bronte, Florinda Di Piazza, Sergio Rizzo

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)


Breast cancer is the most frequent carcinoma and second most common cause of cancer-related mortality in postmenopausal women. The acquisition of somatic mutations represents the main mechanism through which cancer cells overcome physiological cellular signaling pathways (e.g., PI3K/Akt/mTOR, PTEN, TP53). To date, diagnosis and metastasis monitoring is mainly carried out through tissue biopsy and/or re-biopsy, a very invasive procedure limited only to certain locations and not always feasible in clinical practice. In order to improve disease monitoring over time and to avoid painful procedure such as tissue biopsy, liquid biopsy may represent a new precious tool. Indeed, it represents a basin of “new generation” biomarkers that are spread into the bloodstream from both primary and metastatic sites. Moreover, elevated concentrations of circulating tumor DNA (ctDNA) as well as circulating tumor cells (CTCs) have been found in blood plasma of patients with various tumor types. Nowadays, several new approaches have been introduced for the detection and characterization of CTCs and ctDNA, allowing a real-time monitoring of tumor evolution. This review is focused on the clinical relevance of liquid biopsy in breast cancer and will provide an update concerning CTCs and ctDNA utility as a tool for breast cancer patient monitoring during the course of disease.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaTumor Biology
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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