A genomic map of climate adaptation in Mediterranean cattle breeds

Baldassare Portolano, Salvatore Mastrangelo, Véronique Alary, Roberta Ciampolini, Olivier Pineau, Christina Ligda, Denis Laloë, Ismaïl Boujenane, Nadhira Saïdi-Mehtar, Katayoun Moazami-Goudarzi, Emmanuelle Jousselin, Laurence Flori, Sophie Thévenon, Clementina Rodellar, Charles-Henri Moulin, Juan-Vicente Delgado, Amparo Martinez, Tiziana Sechi, Sara Casu, François Casabianca & 15 others Vincenzo Landi, Anne Lauvie, Georgia Hadjipavlou, Mathieu Gautier, Nadjet Boushaba, Guilhem Sempéré, Mona-Abdelzaher Osman, Armelle Coeur D'Acier, Dimitrios Tsiokos, Ahmed El-Beltagi, Corinne Coquelle, Dalal Menni, Abdelillah Araba, Philippe Lecomte, Caroline Marinthe

Risultato della ricerca: Article

Abstract

Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations.
Lingua originaleEnglish
pagine (da-a)1009-1029
Numero di pagine21
RivistaMolecular Ecology
Volume28
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cita questo

Portolano, B., Mastrangelo, S., Alary, V., Ciampolini, R., Pineau, O., Ligda, C., ... Marinthe, C. (2019). A genomic map of climate adaptation in Mediterranean cattle breeds. Molecular Ecology, 28, 1009-1029.

A genomic map of climate adaptation in Mediterranean cattle breeds. / Portolano, Baldassare; Mastrangelo, Salvatore; Alary, Véronique; Ciampolini, Roberta; Pineau, Olivier; Ligda, Christina; Laloë, Denis; Boujenane, Ismaïl; Saïdi-Mehtar, Nadhira; Moazami-Goudarzi, Katayoun; Jousselin, Emmanuelle; Flori, Laurence; Thévenon, Sophie; Rodellar, Clementina; Moulin, Charles-Henri; Delgado, Juan-Vicente; Martinez, Amparo; Sechi, Tiziana; Casu, Sara; Casabianca, François; Landi, Vincenzo; Lauvie, Anne; Hadjipavlou, Georgia; Gautier, Mathieu; Boushaba, Nadjet; Sempéré, Guilhem; Osman, Mona-Abdelzaher; Coeur D'Acier, Armelle; Tsiokos, Dimitrios; El-Beltagi, Ahmed; Coquelle, Corinne; Menni, Dalal; Araba, Abdelillah; Lecomte, Philippe; Marinthe, Caroline.

In: Molecular Ecology, Vol. 28, 2019, pag. 1009-1029.

Risultato della ricerca: Article

Portolano, B, Mastrangelo, S, Alary, V, Ciampolini, R, Pineau, O, Ligda, C, Laloë, D, Boujenane, I, Saïdi-Mehtar, N, Moazami-Goudarzi, K, Jousselin, E, Flori, L, Thévenon, S, Rodellar, C, Moulin, C-H, Delgado, J-V, Martinez, A, Sechi, T, Casu, S, Casabianca, F, Landi, V, Lauvie, A, Hadjipavlou, G, Gautier, M, Boushaba, N, Sempéré, G, Osman, M-A, Coeur D'Acier, A, Tsiokos, D, El-Beltagi, A, Coquelle, C, Menni, D, Araba, A, Lecomte, P & Marinthe, C 2019, 'A genomic map of climate adaptation in Mediterranean cattle breeds' Molecular Ecology, vol. 28, pagg. 1009-1029.
Portolano B, Mastrangelo S, Alary V, Ciampolini R, Pineau O, Ligda C e altri. A genomic map of climate adaptation in Mediterranean cattle breeds. Molecular Ecology. 2019;28:1009-1029.
Portolano, Baldassare ; Mastrangelo, Salvatore ; Alary, Véronique ; Ciampolini, Roberta ; Pineau, Olivier ; Ligda, Christina ; Laloë, Denis ; Boujenane, Ismaïl ; Saïdi-Mehtar, Nadhira ; Moazami-Goudarzi, Katayoun ; Jousselin, Emmanuelle ; Flori, Laurence ; Thévenon, Sophie ; Rodellar, Clementina ; Moulin, Charles-Henri ; Delgado, Juan-Vicente ; Martinez, Amparo ; Sechi, Tiziana ; Casu, Sara ; Casabianca, François ; Landi, Vincenzo ; Lauvie, Anne ; Hadjipavlou, Georgia ; Gautier, Mathieu ; Boushaba, Nadjet ; Sempéré, Guilhem ; Osman, Mona-Abdelzaher ; Coeur D'Acier, Armelle ; Tsiokos, Dimitrios ; El-Beltagi, Ahmed ; Coquelle, Corinne ; Menni, Dalal ; Araba, Abdelillah ; Lecomte, Philippe ; Marinthe, Caroline. / A genomic map of climate adaptation in Mediterranean cattle breeds. In: Molecular Ecology. 2019 ; Vol. 28. pagg. 1009-1029.
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title = "A genomic map of climate adaptation in Mediterranean cattle breeds",
abstract = "Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations.",
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T1 - A genomic map of climate adaptation in Mediterranean cattle breeds

AU - Portolano, Baldassare

AU - Mastrangelo, Salvatore

AU - Alary, Véronique

AU - Ciampolini, Roberta

AU - Pineau, Olivier

AU - Ligda, Christina

AU - Laloë, Denis

AU - Boujenane, Ismaïl

AU - Saïdi-Mehtar, Nadhira

AU - Moazami-Goudarzi, Katayoun

AU - Jousselin, Emmanuelle

AU - Flori, Laurence

AU - Thévenon, Sophie

AU - Rodellar, Clementina

AU - Moulin, Charles-Henri

AU - Delgado, Juan-Vicente

AU - Martinez, Amparo

AU - Sechi, Tiziana

AU - Casu, Sara

AU - Casabianca, François

AU - Landi, Vincenzo

AU - Lauvie, Anne

AU - Hadjipavlou, Georgia

AU - Gautier, Mathieu

AU - Boushaba, Nadjet

AU - Sempéré, Guilhem

AU - Osman, Mona-Abdelzaher

AU - Coeur D'Acier, Armelle

AU - Tsiokos, Dimitrios

AU - El-Beltagi, Ahmed

AU - Coquelle, Corinne

AU - Menni, Dalal

AU - Araba, Abdelillah

AU - Lecomte, Philippe

AU - Marinthe, Caroline

PY - 2019

Y1 - 2019

N2 - Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations.

AB - Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate subtypes. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate variations highlighted several biological functions involved in Mediterranean climate adaptation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV exposure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different populations suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support conservation of these populations.

UR - http://hdl.handle.net/10447/351384

UR - https://onlinelibrary.wiley.com/doi/abs/10.1111/mec.15004

M3 - Article

VL - 28

SP - 1009

EP - 1029

JO - Molecular Ecology

JF - Molecular Ecology

SN - 0962-1083

ER -