A flexible approach to the crossing hazards problem

Vito Michele Rosario Muggeo, Miriam Tagliavia

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

We propose a simple and flexible framework for the crossing hazards problem. The method is not confined to two-sample problems, but it may also work with continuous exposure variables whose effect changes its sign atsome time point of the observed follow-up time. Penalized partial likelihood estimation relies upon the assumption of a smooth hazard ratio via low-rank basis splines with a conventional difference penalty to ensure smoothness, and additional ad-hoc penalties to obtain restricted estimates useful in the context of crossinghazards. The framework naturally also leads to statistical test which has good power for revealing a global effect under several alternatives, including crossing hazards. We provide results from a real-data analysis andfrom some simulations to illustrate empirically the performance of the proposed approach as compared to possiblealternatives.
Lingua originaleEnglish
pagine (da-a)1947-1957
Numero di pagine11
RivistaStatistics in Medicine
Volume29
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability

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