A first comparative map of copy number variations in the sheep genome

Baldassare Portolano, Luca Fontanesi, Occidente, Pier L. Martelli, Beretti, Michela Colombo, Russo, Stefania Dall'Olio, Matassino, Rita Casadio, Vincenzo Russo, Portolano

Risultato della ricerca: Articlepeer review

69 Citazioni (Scopus)

Abstract

We carried out a cross species cattle–sheep array comparative genome hybridization experiment to identify copy number variations (CNVs) in the sheep genome analysing ewes of Italian dairy or dual-purpose breeds (Bagnolese, Comisana, Laticauda, Massese, Sarda, and Valle del Belice) using a tiling oligonucleotide arraywith ~385,000 probes designed on the bovine genome. We identified 135 CNV regions (CNVRs; 24 reported in more than one animal) covering ~10.5 Mb of the virtual sheep genome referred to the bovine genome (0.398%) with a mean and a median equal to 77.6 and 55.9 kb, respectively. A comparative analysis between the identified sheep CNVRs and those reported in cattle and goat genomes indicated that overlaps betweensheep and both other species CNVRs are highly significant (Pb0.0001), suggesting that several chromosome regions might contain recurrent interspecies CNVRs. Many sheep CNVRs include genes with importantbiological functions. Further studies are needed to evaluate their functional relevance.
Lingua originaleEnglish
pagine (da-a)158-165
Numero di pagine8
RivistaGenomics
Volume97
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Genetics

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