A Deep Learning Network for Exploiting Positional Information in Nucleosome Related Sequences

Salvatore Gaglio, Giosue' Lo Bosco, Mattia Antonino Di Gangi, Giosué Lo Bosco, Riccardo Rizzo, Riccardo Rizzo

Risultato della ricerca: Conference contribution

7 Citazioni (Scopus)

Abstract

A nucleosome is a DNA-histone complex, wrapping about 150 pairs of double-stranded DNA. The role of nucleosomes is to pack the DNA into the nucleus of the Eukaryote cells to form the Chromatin. Nucleosome positioning genome wide play an important role in the regulation of cell type-specific gene activities. Several biological studies haveshown sequence specificity of nucleosome presence, clearly underlined by the organization of precise nucleotides substrings. Taking into consideration such advances, the identification of nucleosomes on a genomic scale has been successfully performed by DNA sequence features representation and classical supervised classification methods such as Support Vector Machines and Logistic regression. The goal of this work is to propose a classification method for nucleosome positioning that, differentlyfrom the proposed method so far, does not make any use of a sequence feature extraction step. Deep neural networks (DNN) or deep learning models, were proved to be able to extract automatically useful features from input patterns. Under this framework, Long Short-Term Memory (LSTM) is a recurrent unit that reads a sequence one step at a time and can exploit long range relations. In this work, we propose a DNN model for nucleosome identification on sequences from three different species. Our experiments show that it outperforms classical methods in two of the three data sets and give promising results also for the other
Lingua originaleEnglish
Titolo della pubblicazione ospiteBioinformatics and Biomedical Engineering, 5th International Work-Conference, IWBBIO 2017, Granada, Spain, April 26–28, 2017, Proceedings, Part II
Pagine524-533
Numero di pagine10
Stato di pubblicazionePublished - 2017

Serie di pubblicazioni

NomeLECTURE NOTES IN COMPUTER SCIENCE

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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    Gaglio, S., Lo Bosco, G., Di Gangi, M. A., Lo Bosco, G., Rizzo, R., & Rizzo, R. (2017). A Deep Learning Network for Exploiting Positional Information in Nucleosome Related Sequences. In Bioinformatics and Biomedical Engineering, 5th International Work-Conference, IWBBIO 2017, Granada, Spain, April 26–28, 2017, Proceedings, Part II (pagg. 524-533). (LECTURE NOTES IN COMPUTER SCIENCE).