A COMPOSITE PLLA SCAFFOLD FOR REGENERATION OF COMPLEX TISSUES

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Abstract

A composite biodegradable scaffold incorporating an integrated network of synthetic blood vessels was designed and prepared, in line with the requirements of a scaffold effectively supporting the regeneration of highly vascularized tissues. In other words, this composite scaffold should allow the regeneration of complex injured tissue (e.g. dermis) and, at the same time, favour the development of a vascular network on its inner, i.e. a 3D polymeric scaffolds embedding synthetic blood vessel-like structures for nutrient supply and metabolite removal. PLLA assures a high degree of biocompatibility and a low level of inflammation response upon implantation, while the embedded tubular vessel-like structures with a porous internal surface and a porous wall should give rise to a successful in-vitro growth of the endothelial cells, leading to the generation of new vessels. In order to realize the composite scaffold, a technique for integration of vessel-like scaffolds into porous PLLA scaffolds prepared via TIPS was assessed. The scaffolds obtained present a porous bulk with a high degree of interconnection. Moreover, the vessel-like scaffold(s) are completely embedded into the porous structure produced via TIPS and a continuous porous structure at the border of the vessel-like scaffold in communication with the macropores of the “main” scaffold was detected. A preliminary in-vitro coculture test showed that both the cell types seeded into the composite scaffold are able to grow and mature towards a ”primordial” tissue.
Lingua originaleEnglish
pagine (da-a)571-574
Numero di pagine4
RivistaInternational Journal of Material Forming
Volume2010
Stato di pubblicazionePublished - 2010

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Scaffolds
Tissue
Composite materials
Blood vessel prostheses
Endothelial cells
Scaffolds (biology)
Metabolites
Biocompatibility
Nutrients
Communication

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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title = "A COMPOSITE PLLA SCAFFOLD FOR REGENERATION OF COMPLEX TISSUES",
abstract = "A composite biodegradable scaffold incorporating an integrated network of synthetic blood vessels was designed and prepared, in line with the requirements of a scaffold effectively supporting the regeneration of highly vascularized tissues. In other words, this composite scaffold should allow the regeneration of complex injured tissue (e.g. dermis) and, at the same time, favour the development of a vascular network on its inner, i.e. a 3D polymeric scaffolds embedding synthetic blood vessel-like structures for nutrient supply and metabolite removal. PLLA assures a high degree of biocompatibility and a low level of inflammation response upon implantation, while the embedded tubular vessel-like structures with a porous internal surface and a porous wall should give rise to a successful in-vitro growth of the endothelial cells, leading to the generation of new vessels. In order to realize the composite scaffold, a technique for integration of vessel-like scaffolds into porous PLLA scaffolds prepared via TIPS was assessed. The scaffolds obtained present a porous bulk with a high degree of interconnection. Moreover, the vessel-like scaffold(s) are completely embedded into the porous structure produced via TIPS and a continuous porous structure at the border of the vessel-like scaffold in communication with the macropores of the “main” scaffold was detected. A preliminary in-vitro coculture test showed that both the cell types seeded into the composite scaffold are able to grow and mature towards a ”primordial” tissue.",
author = "Brucato, {Valerio Maria Bartolo} and Giulio Ghersi and {La Carrubba}, Vincenzo and {Carfi' Pavia}, Francesco",
year = "2010",
language = "English",
volume = "2010",
pages = "571--574",
journal = "International Journal of Material Forming",
issn = "1960-6206",
publisher = "Springer Paris",

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TY - JOUR

T1 - A COMPOSITE PLLA SCAFFOLD FOR REGENERATION OF COMPLEX TISSUES

AU - Brucato, Valerio Maria Bartolo

AU - Ghersi, Giulio

AU - La Carrubba, Vincenzo

AU - Carfi' Pavia, Francesco

PY - 2010

Y1 - 2010

N2 - A composite biodegradable scaffold incorporating an integrated network of synthetic blood vessels was designed and prepared, in line with the requirements of a scaffold effectively supporting the regeneration of highly vascularized tissues. In other words, this composite scaffold should allow the regeneration of complex injured tissue (e.g. dermis) and, at the same time, favour the development of a vascular network on its inner, i.e. a 3D polymeric scaffolds embedding synthetic blood vessel-like structures for nutrient supply and metabolite removal. PLLA assures a high degree of biocompatibility and a low level of inflammation response upon implantation, while the embedded tubular vessel-like structures with a porous internal surface and a porous wall should give rise to a successful in-vitro growth of the endothelial cells, leading to the generation of new vessels. In order to realize the composite scaffold, a technique for integration of vessel-like scaffolds into porous PLLA scaffolds prepared via TIPS was assessed. The scaffolds obtained present a porous bulk with a high degree of interconnection. Moreover, the vessel-like scaffold(s) are completely embedded into the porous structure produced via TIPS and a continuous porous structure at the border of the vessel-like scaffold in communication with the macropores of the “main” scaffold was detected. A preliminary in-vitro coculture test showed that both the cell types seeded into the composite scaffold are able to grow and mature towards a ”primordial” tissue.

AB - A composite biodegradable scaffold incorporating an integrated network of synthetic blood vessels was designed and prepared, in line with the requirements of a scaffold effectively supporting the regeneration of highly vascularized tissues. In other words, this composite scaffold should allow the regeneration of complex injured tissue (e.g. dermis) and, at the same time, favour the development of a vascular network on its inner, i.e. a 3D polymeric scaffolds embedding synthetic blood vessel-like structures for nutrient supply and metabolite removal. PLLA assures a high degree of biocompatibility and a low level of inflammation response upon implantation, while the embedded tubular vessel-like structures with a porous internal surface and a porous wall should give rise to a successful in-vitro growth of the endothelial cells, leading to the generation of new vessels. In order to realize the composite scaffold, a technique for integration of vessel-like scaffolds into porous PLLA scaffolds prepared via TIPS was assessed. The scaffolds obtained present a porous bulk with a high degree of interconnection. Moreover, the vessel-like scaffold(s) are completely embedded into the porous structure produced via TIPS and a continuous porous structure at the border of the vessel-like scaffold in communication with the macropores of the “main” scaffold was detected. A preliminary in-vitro coculture test showed that both the cell types seeded into the composite scaffold are able to grow and mature towards a ”primordial” tissue.

UR - http://hdl.handle.net/10447/56277

UR - https://link.springer.com/article/10.1007%2Fs12289-010-0834-9

M3 - Article

VL - 2010

SP - 571

EP - 574

JO - International Journal of Material Forming

JF - International Journal of Material Forming

SN - 1960-6206

ER -