A combined genome-wide approach identifies a new potential candidate marker associated with the coat color sidedness in cattle

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Abstract

Coat color is one of the most important phenotypic features in livestock breeds. Cinisara is a local cattle breed generally of uniform black color which occasionally presents a particular phenotype, with animals typically display a white band along their spine, from the head to the tail, and on the ventral line (color sidedness). Therefore, this breed provides an ideal model to study the genetic components underlying phenotypic variation in coat color. A total of 63 animals, ten with sidedness phenotype and 53 with uniform black color were genotyped with Illumina Bovine 50 K. The comparison among genome-wide association study and FST analysis revealed a single nucleotide polymorphism (SNP), ARS-BFGL-NGS-55928, significantly associated with the trait. Only one gene (PLK2)was annotated near the associated SNP in a window of ±200 kb. The protein encoded by this gene is a member of the polo-like kinases, the same family of several known coat-color candidate genes. Based on the reported results, we draw the possible conclusion that the identified marker is potentially associated with the coat color sidedness in Cinisara. The local breeds with their genetic variability represent an important resource and model to study the genetic basis affecting peculiar traits. Future studies would be particularly relevant to refine these results and to better understand the genetic basis for this phenotype.
Lingua originaleEnglish
pagine (da-a)91-95
Numero di pagine5
RivistaLivestock Science
Volume225
Stato di pubblicazionePublished - 2019

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Color
Genome
genome
color
cattle
breeds
Phenotype
phenotype
single nucleotide polymorphism
Single Nucleotide Polymorphism
genes
Genome-Wide Association Study
cattle breeds
Livestock
phenotypic variation
Genes
Tail
animals
phosphotransferases (kinases)
Spine

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

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@article{ffb552ecb82d4ec2bd7779c4a15225d7,
title = "A combined genome-wide approach identifies a new potential candidate marker associated with the coat color sidedness in cattle",
abstract = "Coat color is one of the most important phenotypic features in livestock breeds. Cinisara is a local cattle breed generally of uniform black color which occasionally presents a particular phenotype, with animals typically display a white band along their spine, from the head to the tail, and on the ventral line (color sidedness). Therefore, this breed provides an ideal model to study the genetic components underlying phenotypic variation in coat color. A total of 63 animals, ten with sidedness phenotype and 53 with uniform black color were genotyped with Illumina Bovine 50 K. The comparison among genome-wide association study and FST analysis revealed a single nucleotide polymorphism (SNP), ARS-BFGL-NGS-55928, significantly associated with the trait. Only one gene (PLK2)was annotated near the associated SNP in a window of ±200 kb. The protein encoded by this gene is a member of the polo-like kinases, the same family of several known coat-color candidate genes. Based on the reported results, we draw the possible conclusion that the identified marker is potentially associated with the coat color sidedness in Cinisara. The local breeds with their genetic variability represent an important resource and model to study the genetic basis affecting peculiar traits. Future studies would be particularly relevant to refine these results and to better understand the genetic basis for this phenotype.",
author = "Baldassare Portolano and Gianluca Sottile and Salvatore Mastrangelo and Sutera, {Anna Maria} and {Di Gerlando}, Rosalia and Marco Tolone and Sardina, {Maria Teresa}",
year = "2019",
language = "English",
volume = "225",
pages = "91--95",
journal = "Livestock Science",
issn = "1871-1413",
publisher = "Elsevier",

}

TY - JOUR

T1 - A combined genome-wide approach identifies a new potential candidate marker associated with the coat color sidedness in cattle

AU - Portolano, Baldassare

AU - Sottile, Gianluca

AU - Mastrangelo, Salvatore

AU - Sutera, Anna Maria

AU - Di Gerlando, Rosalia

AU - Tolone, Marco

AU - Sardina, Maria Teresa

PY - 2019

Y1 - 2019

N2 - Coat color is one of the most important phenotypic features in livestock breeds. Cinisara is a local cattle breed generally of uniform black color which occasionally presents a particular phenotype, with animals typically display a white band along their spine, from the head to the tail, and on the ventral line (color sidedness). Therefore, this breed provides an ideal model to study the genetic components underlying phenotypic variation in coat color. A total of 63 animals, ten with sidedness phenotype and 53 with uniform black color were genotyped with Illumina Bovine 50 K. The comparison among genome-wide association study and FST analysis revealed a single nucleotide polymorphism (SNP), ARS-BFGL-NGS-55928, significantly associated with the trait. Only one gene (PLK2)was annotated near the associated SNP in a window of ±200 kb. The protein encoded by this gene is a member of the polo-like kinases, the same family of several known coat-color candidate genes. Based on the reported results, we draw the possible conclusion that the identified marker is potentially associated with the coat color sidedness in Cinisara. The local breeds with their genetic variability represent an important resource and model to study the genetic basis affecting peculiar traits. Future studies would be particularly relevant to refine these results and to better understand the genetic basis for this phenotype.

AB - Coat color is one of the most important phenotypic features in livestock breeds. Cinisara is a local cattle breed generally of uniform black color which occasionally presents a particular phenotype, with animals typically display a white band along their spine, from the head to the tail, and on the ventral line (color sidedness). Therefore, this breed provides an ideal model to study the genetic components underlying phenotypic variation in coat color. A total of 63 animals, ten with sidedness phenotype and 53 with uniform black color were genotyped with Illumina Bovine 50 K. The comparison among genome-wide association study and FST analysis revealed a single nucleotide polymorphism (SNP), ARS-BFGL-NGS-55928, significantly associated with the trait. Only one gene (PLK2)was annotated near the associated SNP in a window of ±200 kb. The protein encoded by this gene is a member of the polo-like kinases, the same family of several known coat-color candidate genes. Based on the reported results, we draw the possible conclusion that the identified marker is potentially associated with the coat color sidedness in Cinisara. The local breeds with their genetic variability represent an important resource and model to study the genetic basis affecting peculiar traits. Future studies would be particularly relevant to refine these results and to better understand the genetic basis for this phenotype.

UR - http://hdl.handle.net/10447/360320

UR - https://www.sciencedirect.com/science/article/abs/pii/S1871141318305432

M3 - Article

VL - 225

SP - 91

EP - 95

JO - Livestock Science

JF - Livestock Science

SN - 1871-1413

ER -