A Case of Epididymo-orchitis after intravesical bacille Calmette-Guérin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection

Paola Di Carlo, Claudia Colomba, Antonio Cascio, Claudia Gioe', Giuliana Guadagnino, Lucia Siracusa, Marcello Trizzino

Risultato della ricerca: Article

9 Citazioni (Scopus)


Background: Intravesical instillation of bacille Calmette-Guérin (BCG) has been established as efficient therapy for superficial bladder carcinoma. Overall, intravesical BCG is well tolerated and results in complications of less than 5 %. However, adverse effects such as granulomatous prostatitis, pneumonitis, hepatitis, sepsis, and hypersensitivity reactions may occur. The reported rate for tuberculous orchitis after BCG intravesical therapy is 0.4 %. Findings: We report a case of monolateral tuberculous orchitis occurring one month after the second course of intravescical instillation of bacille Calmette-Guérin in a patient with proven superficial bladder carcinoma and latent tuberculosis infection. Conclusions: In our opinion intravesical instillation of BCG should be considered on an individual patient basis, with full patient disclosure of the potentially significant risks. A screening with an intradermal Mantoux before starting the first cycle of BCG instillation should be recommended and isoniazid would be indicated as the treatment for latent tuberculosis infection.
Lingua originaleEnglish
pagine (da-a)25-27
Numero di pagine3
RivistaInfectious Agents and Cancer
Stato di pubblicazionePublished - 2016


All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Cancer Research
  • Infectious Diseases

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