A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study.

Paolo Ragonese, Nunzia Alessandra Losignore, Antonella Veneziano, Antonello Pala, Ada Francia, Katrin Plewnia, Mariarosa Rottoli, Davide Maimone, Maura Frigo, Paolo Confalonieri, Enrico Montanari

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Abstract

INTRODUCTION: Depression and anxiety are common among patients with multiple sclerosis (MS) and are frequently present at the time of MS diagnosis.METHODS: POSIDONIA was a 12-month, observational, prospective study conducted in Italy to evaluate the impact of disease-modifying treatment (DMT) on emotional burden in patients with recently-diagnosed MS. The Hospital Anxiety and Depression Scale (HADS), specifically HADS anxiety (HADS-A) and depression (HADS-D) subscale scores, the Short-Form 36 Health Survey (SF-36) and the Impact of Event Scale - Revised (IES-R) were used to measure patient-reported outcomes. The Hamilton Depression Rating Scale (HDRS), HDRS-17, was used as a measure of healthcare provider-reported outcomes. The primary study outcome was change from baseline in feelings of anxiety and depression over 12months (via HADS).RESULTS: Of 250 enrolled patients, 222 (88.8%) completed the study. At baseline, mean HADS total, HADS-A and HADS-D subscale scores were within the normal range. There were no significant changes over time in mean HADS total and HADS-A and HADS-D subscale scores, although the subgroup of patients with baseline scores indicative of anxiety or depression tended to improve over time. Both the HDRS and IES-R total scores improved over time, but there were no statistically significant changes in SF-36.CONCLUSION: In the patient population of the POSIDONIA study depression and anxiety were present in a minority of patients thus not allowing to detect the impact of starting DMT. However DMT appears to have a positive effect in patients with measurable anxiety or depression at baseline.
Lingua originaleEnglish
pagine (da-a)105-109
Numero di pagine5
RivistaJournal of the Neurological Sciences
Volume364
Stato di pubblicazionePublished - 2016

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Ragonese, P., Losignore, N. A., Veneziano, A., Pala, A., Francia, A., Plewnia, K., Rottoli, M., Maimone, D., Frigo, M., Confalonieri, P., & Montanari, E. (2016). A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study. Journal of the Neurological Sciences, 364, 105-109.