Abstract
α-N-Protected amino acid hydrazides (1) readily reacted with NaBH4 to afford 5-substituted 4,5-dihydro-1,2,4-triazin-3(2H)-one derivatives 2 in good yields. Unfortunately, the reaction caused partial racemization at the α-amino acidic carbon atom of the starting hydrazide. A mechanism, supported by experimental evidence, has been proposed in an attempt to explain this to date unprecedented reaction. The structure of compounds 2 was confirmed by X-ray structural analysis. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Lingua originale | English |
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pagine (da-a) | 2638-2643 |
Numero di pagine | 6 |
Rivista | European Journal of Organic Chemistry |
Stato di pubblicazione | Published - 2006 |
All Science Journal Classification (ASJC) codes
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- ???subjectarea.asjc.1600.1605???