4-Diazopyrazole Derivatives as Potential New Antibiofilm Agents

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)

Abstract

BACKGROUND: The recognition that chronic infections and infections associated with medical devices are biofilm related has been the impulse for investigating the antibiofilm properties of some diazopyrazoles biologically active as antimicrobials.METHODS: The susceptibility of staphylococcal biofilms was determined at concentrations ranging from 25 to 1.5 microg/ml using crystal violet and methylthiazotetrazolium (MTT) staining. In the case of Candida albicans, we first assessed the anti-germ tube formation effect of 4-NO2 (compound 1c) and then we evaluated its antibiofilm activity at concentrations ranging from 100 to 6.2 microg/ml.RESULTS: All the compounds were active against reference staphylococcal biofilm strains at the maximum tested concentration of 25 microg/ml; despite its remarkable activity as germ tube inhibitor, compound 1c showed weak activity against C. albicans biofilms at 100 microg/ml.CONCLUSION: 4-Diazopyrazoles represent an interesting source of antimicrobial compounds in the development of new antibiofilm agents.
Lingua originaleEnglish
pagine (da-a)456-462
Numero di pagine7
RivistaChemotherapy
Volume54
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Entra nei temi di ricerca di '4-Diazopyrazole Derivatives as Potential New Antibiofilm Agents'. Insieme formano una fingerprint unica.

Cita questo