Abstract

Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.
Lingua originaleEnglish
Numero di pagine8
RivistaJournal of Oncology
Volume2019
Stato di pubblicazionePublished - 2019

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Immunotherapy
Melanoma
T-Lymphocytes
Neoplasms
Vaccination
Therapeutics
Research

All Science Journal Classification (ASJC) codes

  • Oncology

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title = "Γ δ T Cell-Based Immunotherapy in Melanoma: State of the Art",
abstract = "Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.",
author = "Francesco Dieli and {Di Stefano}, {Anna Barbara} and Roberto Pirrello and {Lo Presti}, Elena and Adriana Cordova and Fabio Fulfaro and Gaetana Rinaldi and Serena Meraviglia and Francesca Toia",
year = "2019",
language = "English",
volume = "2019",
journal = "Journal of Oncology",
issn = "1687-8450",
publisher = "Hindawi Publishing Corporation",

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TY - JOUR

T1 - Γ δ T Cell-Based Immunotherapy in Melanoma: State of the Art

AU - Dieli, Francesco

AU - Di Stefano, Anna Barbara

AU - Pirrello, Roberto

AU - Lo Presti, Elena

AU - Cordova, Adriana

AU - Fulfaro, Fabio

AU - Rinaldi, Gaetana

AU - Meraviglia, Serena

AU - Toia, Francesca

PY - 2019

Y1 - 2019

N2 - Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.

AB - Metastatic melanoma is still associated with a poor prognosis, and there is increasing interest in immunotherapy alone or in combination with other adjuvant therapies. Γδ T lymphocytes play a pivot role in the immune response against cancer, but while γδ-based immunotherapy is already a clinical reality for several solid tumors, data on melanoma are still limited and fragmented. This systematic review presents preclinical and clinical evidence for a role of γδ T lymphocytes in immunotherapeutic strategies for advanced melanoma and discusses research state of the art and future perspectives. Current strategies focus on in vivo stimulation, and ex vivo adoptive therapy and vaccination; results are promising, but further studies are needed to better investigate the interactions in tumoral microenvironment and to improve clinical efficacy of immunotherapeutic protocols.

UR - http://hdl.handle.net/10447/362684

M3 - Article

VL - 2019

JO - Journal of Oncology

JF - Journal of Oncology

SN - 1687-8450

ER -