γδ cells and tumor microenvironment: A helpful or a dangerous liason?

Serena Meraviglia, Francesco Dieli, Elena Lo Presti, Gabriele Pizzolato, Filippo Mocciaro, Roberto Di Mitri, Filippo Mocciaro, Roberto Di Mitri

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

gamma delta T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. T cells are endowed with antitumor activities, and hence several T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of invitro expanded T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating T cells toward different T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of T cells in cancer immunotherapy.
Lingua originaleEnglish
pagine (da-a)485-492
Numero di pagine8
RivistaDefault journal
Volume103
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cita questo

γδ cells and tumor microenvironment: A helpful or a dangerous liason? / Meraviglia, Serena; Dieli, Francesco; Lo Presti, Elena; Pizzolato, Gabriele; Mocciaro, Filippo; Di Mitri, Roberto; Mocciaro, Filippo; Di Mitri, Roberto.

In: Default journal, Vol. 103, 2018, pag. 485-492.

Risultato della ricerca: Article

Meraviglia, Serena ; Dieli, Francesco ; Lo Presti, Elena ; Pizzolato, Gabriele ; Mocciaro, Filippo ; Di Mitri, Roberto ; Mocciaro, Filippo ; Di Mitri, Roberto. / γδ cells and tumor microenvironment: A helpful or a dangerous liason?. In: Default journal. 2018 ; Vol. 103. pagg. 485-492.
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abstract = "gamma delta T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. T cells are endowed with antitumor activities, and hence several T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of invitro expanded T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating T cells toward different T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of T cells in cancer immunotherapy.",
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author = "Serena Meraviglia and Francesco Dieli and {Lo Presti}, Elena and Gabriele Pizzolato and Filippo Mocciaro and {Di Mitri}, Roberto and Filippo Mocciaro and {Di Mitri}, Roberto",
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T1 - γδ cells and tumor microenvironment: A helpful or a dangerous liason?

AU - Meraviglia, Serena

AU - Dieli, Francesco

AU - Lo Presti, Elena

AU - Pizzolato, Gabriele

AU - Mocciaro, Filippo

AU - Di Mitri, Roberto

AU - Mocciaro, Filippo

AU - Di Mitri, Roberto

PY - 2018

Y1 - 2018

N2 - gamma delta T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. T cells are endowed with antitumor activities, and hence several T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of invitro expanded T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating T cells toward different T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of T cells in cancer immunotherapy.

AB - gamma delta T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. T cells are endowed with antitumor activities, and hence several T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of invitro expanded T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating T cells toward different T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of T cells in cancer immunotherapy.

KW - Antigen

KW - T-Cell

KW - gamma-delta; T-Lymphocytes; Tumor Microenvironment

KW - tumor microenviroment; tumor-infiltrating lymphocytes; γδ T cells; Humans; Neoplasms; Receptors

UR - http://hdl.handle.net/10447/356629

M3 - Article

VL - 103

SP - 485

EP - 492

JO - Default journal

JF - Default journal

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