TY - JOUR
T1 - β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche
AU - Zito, Giovanni
AU - Rompolas, Panteleimon
AU - Zito, Giovanni
AU - Deschene, Elizabeth R.
AU - Sun, Thomas Yang
AU - Zito, Giovanni
AU - Myung, Peggy
AU - Saotome, Ichiko
AU - Taketo, Makoto M.
AU - Greco, Valentina
PY - 2014
Y1 - 2014
N2 - Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
AB - Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
KW - Animals; Cell Differentiation; Cell Division; Hair; Hair Follicle; Ligands; Mice; Models
KW - Biological; Mutation; Stem Cell Niche; Stem Cells; Tamoxifen; Up-Regulation; Wnt Proteins; beta Catenin; Wnt Signaling Pathway; Medicine (all); Multidisciplinary
KW - Animals; Cell Differentiation; Cell Division; Hair; Hair Follicle; Ligands; Mice; Models
KW - Biological; Mutation; Stem Cell Niche; Stem Cells; Tamoxifen; Up-Regulation; Wnt Proteins; beta Catenin; Wnt Signaling Pathway; Medicine (all); Multidisciplinary
UR - http://hdl.handle.net/10447/253992
UR - http://www.sciencemag.org/content/343/6177/1353.full.pdf
M3 - Article
VL - 343
SP - 1353
EP - 1356
JO - Science
JF - Science
SN - 0036-8075
ER -