β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche

Giovanni Zito, Peggy Myung, Ichiko Saotome, Makoto M. Taketo, Valentina Greco, Panteleimon Rompolas, Giovanni Zito, Elizabeth R. Deschene, Thomas Yang Sun

Risultato della ricerca: Article

61 Citazioni (Scopus)

Abstract

Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
Lingua originaleEnglish
pagine (da-a)1353-1356
Numero di pagine4
RivistaScience
Volume343
Stato di pubblicazionePublished - 2014

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Stem Cell Niche
Catenins
Hair
Growth
Regeneration
Stem Cells
Hair Follicle
Cell Division
Ligands
Skin

All Science Journal Classification (ASJC) codes

  • General

Cita questo

Zito, G., Myung, P., Saotome, I., Taketo, M. M., Greco, V., Rompolas, P., ... Sun, T. Y. (2014). β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science, 343, 1353-1356.

β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. / Zito, Giovanni; Myung, Peggy; Saotome, Ichiko; Taketo, Makoto M.; Greco, Valentina; Rompolas, Panteleimon; Zito, Giovanni; Deschene, Elizabeth R.; Sun, Thomas Yang.

In: Science, Vol. 343, 2014, pag. 1353-1356.

Risultato della ricerca: Article

Zito, G, Myung, P, Saotome, I, Taketo, MM, Greco, V, Rompolas, P, Zito, G, Deschene, ER & Sun, TY 2014, 'β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche', Science, vol. 343, pagg. 1353-1356.
Zito G, Myung P, Saotome I, Taketo MM, Greco V, Rompolas P e altri. β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science. 2014;343:1353-1356.
Zito, Giovanni ; Myung, Peggy ; Saotome, Ichiko ; Taketo, Makoto M. ; Greco, Valentina ; Rompolas, Panteleimon ; Zito, Giovanni ; Deschene, Elizabeth R. ; Sun, Thomas Yang. / β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. In: Science. 2014 ; Vol. 343. pagg. 1353-1356.
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abstract = "Wnt/{\^I}²-catenin signaling is critical for tissue regeneration. However, it is unclear how {\^I}²-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of {\^I}²-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. {\^I}²-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by {\^I}²-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/{\^I}²-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.",
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T1 - β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche

AU - Zito, Giovanni

AU - Myung, Peggy

AU - Saotome, Ichiko

AU - Taketo, Makoto M.

AU - Greco, Valentina

AU - Rompolas, Panteleimon

AU - Zito, Giovanni

AU - Deschene, Elizabeth R.

AU - Sun, Thomas Yang

PY - 2014

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N2 - Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.

AB - Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by β-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/β-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.

KW - Animals; Cell Differentiation; Cell Division; Hair; Hair Follicle; Ligands; Mice; Models, Biological; Mutation; Stem Cell Niche; Stem Cells; Tamoxifen; Up-Regulation; Wnt Proteins; beta Catenin; Wnt Signaling Pathway; Medicine (all); Multidisciplinary

UR - http://hdl.handle.net/10447/253992

UR - http://www.sciencemag.org/content/343/6177/1353.full.pdf

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JO - Science

JF - Science

SN - 0036-8075

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