Wnt/Î²-catenin signaling is critical for tissue regeneration. However, it is unclear how Î²-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of Î²-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. Î²-Catenin activation is sufficient to induce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair regeneration. Wild-type cells are co-opted into new hair growths by Î²-catenin mutant cells, which non-cell autonomously activate Wnt signaling within the neighboring wild-type cells via Wnt ligands. This study demonstrates a mechanism by which Wnt/Î²-catenin signaling controls stem cell-dependent tissue growth non-cell autonomously and advances our understanding of the mechanisms that drive coordinated regeneration.
|Numero di pagine||4|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
Zito, G., Rompolas, P., Zito, G., Deschene, E. R., Sun, T. Y., Myung, P., Saotome, I., Taketo, M. M., & Greco, V. (2014). Î²-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science, 343, 1353-1356.