TUMORI DELLA TIROIDE: REGISTRO REGIONALE DI SICILIA , RETE INTEGRATA DI EPIDEMIOLOGIA CLINICA, BASI MOLECOLARI DELLA PROGRESSIONE NEOPLASTICA E FATTORI DI RISCHIO

    Progetto: Research project

    Dettagli progetto

    Description

    This study proposes an unique model for the study of clinical and molecular epidemiology of thyroid carcinoma due to thegeographical and environmental characteristics of the Island of Sicily. The interest of the project is overwhelming regional interest since it can shed new light on the knowledge about the increased incidence of this class of tumours with obvious positive repercussion on Public Health policy in Sicily and in Italy.A relevant expected result is the identification of the role of known and not known risk factors (especially those to be identified in the volcanic area) including environmental microelements acting as potentially oncogenic factors and/or as endocriune disruptors.A second relevant point to be investigated and demonstrated is the possible relation between molecular characterization andthe biological behaviour of those tumours by correlating gene alterations with evolution and aggressiveness.The molecular characterization of poorly differentiated and dedifferentiated tumours can give useful information for developing innovative therapeutical approach

    Layman's description

    OBIETTIVO GENERALE DEL PROGETTO:1)Aggiornamento prospettico e in serie continua e mantenimento del Registro tumori tiroidei :epidemiologia descrittiva e clinica 2) Arricchimento e consolidamento dell’archivio tessuti neoplastici (Banca DNA)3) Identificazione di fattori di rischio individuali e ambientali per tumori tiroidei 4) Analisi genetico-molecolare dei microcarcinomi e carcinomi poco differenziati

    Key findings

    Salute
    StatoAttivo
    Data di inizio/fine effettiva1/1/07 → …