Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships

Alessia Ajovalasit, Maria Antonietta Sabatino, Sabina Alessi, Clelia Dispenza, Pasquale Picone, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo, Marta Di Carlo, Pasquale Picone

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Abstract

Thin xyloglucan-based hydrogel films have been synthetized and characterized in the prospect of producing wound dressings. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogels have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). Network structure-process-property relationships are discussed on the account of the results of several complementary characterizations: FTIR, rheology, thermal analysis, morphological analysis, moisture retention and swelling measurements. Selected formulations were also subjected to preliminary in vitro cytotoxicity tests. The physical and mechanical properties of some of the xyloglucan-based hydrogel films produced, combined with absence of cytotoxicity, make them suitable candidates for integration with sensors to monitor the wound healing process and further biological investigations in animal models.
Original languageEnglish
Pages (from-to)262-272
Number of pages11
JournalCarbohydrate Polymers
Volume179
Publication statusPublished - 2018

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Ajovalasit, A., Sabatino, M. A., Alessi, S., Dispenza, C., Picone, P., Dispenza, C., Giacomazza, D., Di Carlo, M., Di Carlo, M., & Picone, P. (2018). Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships. Carbohydrate Polymers, 179, 262-272.