Whole grain consumption and human health: an umbrella review of observational studies

Silvio Buscemi, Elena Alonzo, Lucilla Titta, Eleanor Beck, Giuseppe Grosso, Stefano Marventano, Claudia Vetrani, Alessandra Lafranconi, Marilena Vitale, Justyna Godos, Francesca Ghelfi, Daniele Del Rio, Giuseppe Grosso, Maria Tieri, Angelo Gambera, Fabio Galvano, Salvatore Sciacca, Gabriele Riccardi, Sumantra Ray

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evidence of decreased risk of colon cancer and cardiovascular mortality with increased whole grain intake, as well as increased risk of prostate cancer. Limited or insufficient evidence was available for all other outcomes investigated. Overall findings are encouraging for a positive effect of whole grain consumption on certain diseases, especially highly prevalent metabolic diseases, however, uncertainty of some negative associations deserves further attention.
Original languageEnglish
Pages (from-to)668-677
Number of pages10
JournalInternational Journal of Food Sciences and Nutrition
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Food Science


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