Whole-body MRI in patients with lymphoma: collateral findings

Domenico Albano, Massimo Midiri, Massimo Galia, Roberto Lagalla, Ludovico La Grutta, Francesco Di Pietto, Vito Chianca, Caterina Patti, Antonino Mulè, Donatella Narese, Emanuele Grassedonio

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To assess the incidence of collateral findings detected on whole-body magnetic resonance (WB-MRI) scans performed on patients with lymphoma. Materials and methods: 114 patients (65 male; median age 45.2 years, range 15–86) with histologically confirmed lymphoma (47 Hodgkin, 67 Non-Hodgkin) underwent WB-MRI. The collateral findings were classified into three classes, according to their clinical significance, as follows: not or low significant (class 1), moderately or potentially significant (class 2), and significant (class 3). A Chi-square (χ2) test was performed to assess the statistical significance of differences in the incidence of collateral findings based on age (≤50 and >50 years old), gender and histology (Hodgkin and Non-Hodgkin Lymphoma). Results: Ninety-one of 114 patients (79.8 %) had one or more incidental findings on WB-MRI. Collateral findings were more frequent in class 1 (43 %); abnormalities found in 35 patients (30.7 %) were considered potentially significant, whereas seven patients (6.1 %) demonstrated significant collateral findings requiring immediate treatment or further diagnostic evaluation. Collateral findings were more frequent in subjects over 50 years old compared to those of 50 years old or younger; differences were statistical significant (χ2 = 8.42, p < 0.05). There were not statistically significant differences related to gender (χ2 = 0.17, p > 0.05) and histology (χ2 = 0.24, p > 0.05). Conclusion: WB-MRI is an attractive procedure that allows to detect incidental abnormalities of organs not involved by disease offering the opportunity to obtain an early diagnosis of asymptomatic life-threatening diseases.
Original languageEnglish
Pages (from-to)793-800
Number of pages8
JournalLA RADIOLOGIA MEDICA
Volume121
Publication statusPublished - 2016

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Lymphoma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Histology
Incidental Findings
Incidence
Chi-Square Distribution
Early Diagnosis
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Whole-body MRI in patients with lymphoma: collateral findings. / Albano, Domenico; Midiri, Massimo; Galia, Massimo; Lagalla, Roberto; La Grutta, Ludovico; Di Pietto, Francesco; Chianca, Vito; Patti, Caterina; Mulè, Antonino; Narese, Donatella; Grassedonio, Emanuele.

In: LA RADIOLOGIA MEDICA, Vol. 121, 2016, p. 793-800.

Research output: Contribution to journalArticle

Albano, D, Midiri, M, Galia, M, Lagalla, R, La Grutta, L, Di Pietto, F, Chianca, V, Patti, C, Mulè, A, Narese, D & Grassedonio, E 2016, 'Whole-body MRI in patients with lymphoma: collateral findings', LA RADIOLOGIA MEDICA, vol. 121, pp. 793-800.
Albano, Domenico ; Midiri, Massimo ; Galia, Massimo ; Lagalla, Roberto ; La Grutta, Ludovico ; Di Pietto, Francesco ; Chianca, Vito ; Patti, Caterina ; Mulè, Antonino ; Narese, Donatella ; Grassedonio, Emanuele. / Whole-body MRI in patients with lymphoma: collateral findings. In: LA RADIOLOGIA MEDICA. 2016 ; Vol. 121. pp. 793-800.
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abstract = "Purpose: To assess the incidence of collateral findings detected on whole-body magnetic resonance (WB-MRI) scans performed on patients with lymphoma. Materials and methods: 114 patients (65 male; median age 45.2 years, range 15–86) with histologically confirmed lymphoma (47 Hodgkin, 67 Non-Hodgkin) underwent WB-MRI. The collateral findings were classified into three classes, according to their clinical significance, as follows: not or low significant (class 1), moderately or potentially significant (class 2), and significant (class 3). A Chi-square (χ2) test was performed to assess the statistical significance of differences in the incidence of collateral findings based on age (≤50 and >50 years old), gender and histology (Hodgkin and Non-Hodgkin Lymphoma). Results: Ninety-one of 114 patients (79.8 {\%}) had one or more incidental findings on WB-MRI. Collateral findings were more frequent in class 1 (43 {\%}); abnormalities found in 35 patients (30.7 {\%}) were considered potentially significant, whereas seven patients (6.1 {\%}) demonstrated significant collateral findings requiring immediate treatment or further diagnostic evaluation. Collateral findings were more frequent in subjects over 50 years old compared to those of 50 years old or younger; differences were statistical significant (χ2 = 8.42, p < 0.05). There were not statistically significant differences related to gender (χ2 = 0.17, p > 0.05) and histology (χ2 = 0.24, p > 0.05). Conclusion: WB-MRI is an attractive procedure that allows to detect incidental abnormalities of organs not involved by disease offering the opportunity to obtain an early diagnosis of asymptomatic life-threatening diseases.",
author = "Domenico Albano and Massimo Midiri and Massimo Galia and Roberto Lagalla and {La Grutta}, Ludovico and {Di Pietto}, Francesco and Vito Chianca and Caterina Patti and Antonino Mul{\`e} and Donatella Narese and Emanuele Grassedonio",
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T1 - Whole-body MRI in patients with lymphoma: collateral findings

AU - Albano, Domenico

AU - Midiri, Massimo

AU - Galia, Massimo

AU - Lagalla, Roberto

AU - La Grutta, Ludovico

AU - Di Pietto, Francesco

AU - Chianca, Vito

AU - Patti, Caterina

AU - Mulè, Antonino

AU - Narese, Donatella

AU - Grassedonio, Emanuele

PY - 2016

Y1 - 2016

N2 - Purpose: To assess the incidence of collateral findings detected on whole-body magnetic resonance (WB-MRI) scans performed on patients with lymphoma. Materials and methods: 114 patients (65 male; median age 45.2 years, range 15–86) with histologically confirmed lymphoma (47 Hodgkin, 67 Non-Hodgkin) underwent WB-MRI. The collateral findings were classified into three classes, according to their clinical significance, as follows: not or low significant (class 1), moderately or potentially significant (class 2), and significant (class 3). A Chi-square (χ2) test was performed to assess the statistical significance of differences in the incidence of collateral findings based on age (≤50 and >50 years old), gender and histology (Hodgkin and Non-Hodgkin Lymphoma). Results: Ninety-one of 114 patients (79.8 %) had one or more incidental findings on WB-MRI. Collateral findings were more frequent in class 1 (43 %); abnormalities found in 35 patients (30.7 %) were considered potentially significant, whereas seven patients (6.1 %) demonstrated significant collateral findings requiring immediate treatment or further diagnostic evaluation. Collateral findings were more frequent in subjects over 50 years old compared to those of 50 years old or younger; differences were statistical significant (χ2 = 8.42, p < 0.05). There were not statistically significant differences related to gender (χ2 = 0.17, p > 0.05) and histology (χ2 = 0.24, p > 0.05). Conclusion: WB-MRI is an attractive procedure that allows to detect incidental abnormalities of organs not involved by disease offering the opportunity to obtain an early diagnosis of asymptomatic life-threatening diseases.

AB - Purpose: To assess the incidence of collateral findings detected on whole-body magnetic resonance (WB-MRI) scans performed on patients with lymphoma. Materials and methods: 114 patients (65 male; median age 45.2 years, range 15–86) with histologically confirmed lymphoma (47 Hodgkin, 67 Non-Hodgkin) underwent WB-MRI. The collateral findings were classified into three classes, according to their clinical significance, as follows: not or low significant (class 1), moderately or potentially significant (class 2), and significant (class 3). A Chi-square (χ2) test was performed to assess the statistical significance of differences in the incidence of collateral findings based on age (≤50 and >50 years old), gender and histology (Hodgkin and Non-Hodgkin Lymphoma). Results: Ninety-one of 114 patients (79.8 %) had one or more incidental findings on WB-MRI. Collateral findings were more frequent in class 1 (43 %); abnormalities found in 35 patients (30.7 %) were considered potentially significant, whereas seven patients (6.1 %) demonstrated significant collateral findings requiring immediate treatment or further diagnostic evaluation. Collateral findings were more frequent in subjects over 50 years old compared to those of 50 years old or younger; differences were statistical significant (χ2 = 8.42, p < 0.05). There were not statistically significant differences related to gender (χ2 = 0.17, p > 0.05) and histology (χ2 = 0.24, p > 0.05). Conclusion: WB-MRI is an attractive procedure that allows to detect incidental abnormalities of organs not involved by disease offering the opportunity to obtain an early diagnosis of asymptomatic life-threatening diseases.

UR - http://hdl.handle.net/10447/204004

UR - http://link.springer.com/journal/11547

M3 - Article

VL - 121

SP - 793

EP - 800

JO - LA RADIOLOGIA MEDICA

JF - LA RADIOLOGIA MEDICA

SN - 0033-8362

ER -