When the amnestic mild cognitive impairment disappears: characterisation of the memory profile

Roberto Monastero, Carlo Caltagirone, Roberta Perri, Giovanni A. Carlesimo, Laura Serra

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


BACKGROUND/OBJECTIVES:Subjects affected by mild cognitive impairment (MCI) may improve during the observation period. This is the first study investigating qualitative features of memory deficits in subjects affected by reversible MCI [reversible cognitive impairment (RCI)].METHODS:Baseline cognitive and memory performances of 18 subjects affected by amnestic MCI who had normalized cognitive performances at follow-ups were compared with those of 76 amnestic MCI subjects who still showed impaired cognitive performances at the 24-month follow-up (MCI) and with those of a group of 87 matched control subjects (normal controls).RESULTS:Compared with normal controls the memory deficit in the MCI group affected all aspects of explicit long-term memory functioning; in the RCI group, instead, the memory deficit only affected the free recall of verbal material, particularly when the encoding could be improved by the use of semantic strategies.CONCLUSIONS:These results are consistent with the view that the memory deficit in the MCI group is due to a very early degenerative pathology; in the RCI group, instead, a transitory reduction of processing resources, resulting a poor encoding of incoming material, is likely at the origin of the reversible memory disorder.
Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCognitive and Behavioral Neurology
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • General Medicine
  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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