Vitamin K deficiency bleeding leading to a diagnosis of Crohn’s Disease

Chiara Bellia, Antonietta Caruso, Mariasanta Napolitano, Marcello Ciaccio, Giulia Bivona, Luisa Agnello, Bruna Lo Sasso, Lucio Lo Coco, Marcello Ciaccio, Mariasanta Napolitano, Rossella Gnoffo, Felicia Coraci, Filippa Bonura, Silvana Vitale

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results, second level investigations were performed. Endoscopy of the gastrointestinal tract with histological examination revealed a diagnosis of Crohn's disease. Vitamin K deficiency causes the formation of vitamin K-dependent clotting factors that cannot perform their pro-coagulant action. Consequently, patients present with hemorrhagic manifestations. Clinical and laboratory features observed in this patient show that the deficiency of vitamin K-dependent coagulation factors may reveal a complex clinical condition such as an inflammatory bowel disease.
Original languageEnglish
Number of pages4
JournalAnnals of Clinical and Laboratory Science
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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