Vitamin D status and the relationship with bone fragility fractures in HIV-infected patients: A case control study

Antonio Cascio, Alessandra Bitto, Emmanuele Venanzi-Rullo, Alberto Lo Gullo, Luigi Mirarchi, Alberto Lo Gullo, Alberto Lo Gullo, Alberto Lo Gullo, Vincenzo Arcoraci, Francesco Squadrito, Antonino Lasco, Antonino Catalano, Domenico Santoro, Marco Atteritano, Chiara Iaria, Emmanuele Venanzi Rullo, Luigi Mirarchi

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21 Citations (Scopus)


HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age-and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80.58 ± 19.95% vs. 93.80 ± 7.10%, respectively, p < 0.001). VFs were found in 16 patients and in 2 controls. HIV patients with vertebral fractures showed lower stiffness index (SI) (70.75 ± 10.63 vs. 83.36 ± 16.19, respectively, p = 0.045) and lower vitamin D levels (16.20 ± 5.62 vs. 28.14 ± 11.94, respectively, p < 0.02). The majority of VFs (87.5%) were observed in HIV-infected patients with vitamin D insufficiency, and regression analysis showed that vitamin D insufficiency was significantly associated with vertebral fractures (OR 9.15, 95% CI 0.18-0.52, p < 0.04). VFs and are a frequent occurrence in HIV-infected patients and may be associated with vitamin D insufficiency.
Original languageEnglish
Pages (from-to)119-
Number of pages0
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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