Vitamin D status and the relationship with bone fragility fractures in HIV-infected patients: A case control study

Antonio Cascio, Alessandra Bitto, Emmanuele Venanzi-Rullo, Alberto Lo Gullo, Luigi Mirarchi, Vincenzo Arcoraci, Francesco Squadrito, Antonino Lasco, Antonino Catalano, Domenico Santoro, Marco Atteritano, Chiara Iaria, Emmanuele Venanzi Rullo, Luigi Mirarchi

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Abstract

HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age-and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80.58 ± 19.95% vs. 93.80 ± 7.10%, respectively, p < 0.001). VFs were found in 16 patients and in 2 controls. HIV patients with vertebral fractures showed lower stiffness index (SI) (70.75 ± 10.63 vs. 83.36 ± 16.19, respectively, p = 0.045) and lower vitamin D levels (16.20 ± 5.62 vs. 28.14 ± 11.94, respectively, p < 0.02). The majority of VFs (87.5%) were observed in HIV-infected patients with vitamin D insufficiency, and regression analysis showed that vitamin D insufficiency was significantly associated with vertebral fractures (OR 9.15, 95% CI 0.18-0.52, p < 0.04). VFs and are a frequent occurrence in HIV-infected patients and may be associated with vitamin D insufficiency.
Original languageEnglish
Pages (from-to)119-
Number of pages0
JournalInternational Journal of Molecular Sciences
Volume19
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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    Cascio, A., Bitto, A., Venanzi-Rullo, E., Gullo, A. L., Mirarchi, L., Arcoraci, V., Squadrito, F., Lasco, A., Catalano, A., Santoro, D., Atteritano, M., Iaria, C., Venanzi Rullo, E., & Mirarchi, L. (2018). Vitamin D status and the relationship with bone fragility fractures in HIV-infected patients: A case control study. International Journal of Molecular Sciences, 19, 119-.