Context: There is increasing evidence that Vitamin D and its metabolites, besides their well known calcium-related functions, may also exert antiproliferative, pro-differentiating and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on role of Vitamin D and its analogues as chemopreventive drugs in cancer therapy. Method: A systematic review of experimental and clinical studies on Vitamin D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and Conclusion: Experimental and clinical observations suggest that Vitamin D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.
|Number of pages||36|
|Publication status||Published - 2014|
All Science Journal Classification (ASJC) codes