UTILITÀ DI UN BASSO CUT-OFF DI INDICE DI RESISTENZA INTRARENALE NEL PREDIRE ALTERAZIONI VASCOLARI SISTEMICHE PRECOCIIN SOGGETTI CON IPERTENSIONE ARTERIOSA ESSENZIALE

Research output: Contribution to conferenceOther

Abstract

[automatically translated] Recent studies show that the intraparenchymal renal resistance index (RI), classically considered an expression of renal vascular resistance, may have an important role as markers of systemic vascular changes. The IR value of the threshold more often used to identify patients with higher probability of organ damage and mortality was 0.70. However, it was not verified whether a lower cut-off have a greater ability to identify subclinical systemic vascular alterations. The aim of our study was therefore to determine, in patients with essential hypertension (EH), the renal IR value that best preaches the existence of subclinical vascular damage (DVS), My evaluated intima or atherosclerotic plaques in carotid as the presence of thickening (IMTC) or increase in aortic pulse wave velocity (PWVa). They enrolled 168 subjects (aged 30-70 years) with EH. All were subjected to measurement of PWV (by arteriograph) and Doppler ecocolor- of carotid and intrarenal districts. Significant correlations were observed between IR and PWVa (r = 0.304; p <0.001) and between IR and IMTC (r = 0.345; p <0.001), maintained even after adjusting for various confounding factors. The analysis of the ROC curve (AUC = 0678), a value of IR> 0.6 has been shown to possess a significantly higher sensitivity (69.63%) compared to a cutoff of 0.70 (9.63%) in highlighting the presence of DVS, although the reduction specificity to 60,61% compared to 96. 97% equal to the highest IR threshold value. Individuals with IR <0.6 (n = 61) showed lower values of PWVa (18.10 vs. 29.11 m / s; p = 0.003) and IMTC (0.81 vs. 0.97 mm, p <0.001) and a lower prevalence of DVS ( 67.2 vs 87.9%; p = 0.001) than patients with IR> 0.6. Our results seem to indicate as an IR value of 0.60 can better predict and more precociously the existence of a DVS, compared to the traditional value of 0.7.
Original languageItalian
Pages169-169
Number of pages1
Publication statusPublished - 2014

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