Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study.

Gabriele Tripi, Roberto Sacco, Catherine Barthelemy, Gabriele Tripi, Cristina Neri, Andrea Urbani, Stefano Gabriele, Frédérique Bonnet-Brihault, Sonia Cerullo, Joëlle Malvy, Antonio M. Persico

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines ofItalian autistic children up to 8 years of age. The present study aims at replicating these initialfindings in an ethnically distinct sample and at extending them by measuring also the threecomponents of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol.Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls(p50.05). This increase was limited to ASD children aged 8 years (p50.01), and not older(p ¼ 0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic,compulsive/repetitive behaviors (p50.05), although not with overall autism severity. Theseresults confirm the elevation of urinary p-cresol in a sizable set of small autistic children andspur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.
Original languageEnglish
Number of pages8
JournalBiomarkers
Publication statusPublished - 2014

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Autistic Disorder
Compulsive Behavior
4-cresol
Autism Spectrum Disorder
Aromatic compounds
Biomarkers
Urine
4-cresol sulfate

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Tripi, G., Sacco, R., Barthelemy, C., Tripi, G., Neri, C., Urbani, A., ... Persico, A. M. (2014). Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers.

Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. / Tripi, Gabriele; Sacco, Roberto; Barthelemy, Catherine; Tripi, Gabriele; Neri, Cristina; Urbani, Andrea; Gabriele, Stefano; Bonnet-Brihault, Frédérique; Cerullo, Sonia; Malvy, Joëlle; Persico, Antonio M.

In: Biomarkers, 2014.

Research output: Contribution to journalArticle

Tripi, G, Sacco, R, Barthelemy, C, Tripi, G, Neri, C, Urbani, A, Gabriele, S, Bonnet-Brihault, F, Cerullo, S, Malvy, J & Persico, AM 2014, 'Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study.', Biomarkers.
Tripi, Gabriele ; Sacco, Roberto ; Barthelemy, Catherine ; Tripi, Gabriele ; Neri, Cristina ; Urbani, Andrea ; Gabriele, Stefano ; Bonnet-Brihault, Frédérique ; Cerullo, Sonia ; Malvy, Joëlle ; Persico, Antonio M. / Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. In: Biomarkers. 2014.
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AU - Sacco, Roberto

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AU - Neri, Cristina

AU - Urbani, Andrea

AU - Gabriele, Stefano

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AU - Malvy, Joëlle

AU - Persico, Antonio M.

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