Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study.

Gabriele Tripi, Joëlle Malvy, Antonio M. Persico, Roberto Sacco, Catherine Barthelemy, Gabriele Tripi, Cristina Neri, Andrea Urbani, Stefano Gabriele, Frédérique Bonnet-Brihault, Sonia Cerullo

Research output: Contribution to journalArticle

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Abstract

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p50.05). This increase was limited to ASD children aged 8 years (p50.01), and not older (p ¼ 0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p50.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.
Original languageEnglish
Pages (from-to)-
Number of pages8
JournalBiomarkers
Publication statusPublished - 2014

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Autistic Disorder
Compulsive Behavior
4-cresol
Autism Spectrum Disorder
Aromatic compounds
Biomarkers
Urine
4-cresol sulfate

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Clinical Biochemistry

Cite this

Tripi, G., Malvy, J., Persico, A. M., Sacco, R., Barthelemy, C., Tripi, G., ... Cerullo, S. (2014). Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers, -.

Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. / Tripi, Gabriele; Malvy, Joëlle; Persico, Antonio M.; Sacco, Roberto; Barthelemy, Catherine; Tripi, Gabriele; Neri, Cristina; Urbani, Andrea; Gabriele, Stefano; Bonnet-Brihault, Frédérique; Cerullo, Sonia.

In: Biomarkers, 2014, p. -.

Research output: Contribution to journalArticle

Tripi, G, Malvy, J, Persico, AM, Sacco, R, Barthelemy, C, Tripi, G, Neri, C, Urbani, A, Gabriele, S, Bonnet-Brihault, F & Cerullo, S 2014, 'Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study.', Biomarkers, pp. -.
Tripi, Gabriele ; Malvy, Joëlle ; Persico, Antonio M. ; Sacco, Roberto ; Barthelemy, Catherine ; Tripi, Gabriele ; Neri, Cristina ; Urbani, Andrea ; Gabriele, Stefano ; Bonnet-Brihault, Frédérique ; Cerullo, Sonia. / Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. In: Biomarkers. 2014 ; pp. -.
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AU - Malvy, Joëlle

AU - Persico, Antonio M.

AU - Sacco, Roberto

AU - Barthelemy, Catherine

AU - Tripi, Gabriele

AU - Neri, Cristina

AU - Urbani, Andrea

AU - Gabriele, Stefano

AU - Bonnet-Brihault, Frédérique

AU - Cerullo, Sonia

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AB - The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p50.05). This increase was limited to ASD children aged 8 years (p50.01), and not older (p ¼ 0.17). Urinary levels of p-cresol and p-cresylsulfate were associated with stereotypic, compulsive/repetitive behaviors (p50.05), although not with overall autism severity. These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism.

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