Urinary 1H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis

Giovanni Corsello, Mario Giuffre, Serafina Lacerenza, Francesca Garofoli, Luigi Atzori, Angelica Dessì, Antonio Noto, Barbara Liori, Roberta Carboni, Laura Domenica Serpero, Luigi Atzori, Milena Lussu, Pierluigi Caboni, Mauro Stronati, Diego Gazzolo, Vassilios Fanos, Francesca Serraino

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

The purpose of this article is to study one of the most significant causes of neonatal morbidity and mortality: neonatal sepsis. This pathology is due to a bacterial or fungal infection acquired during the perinatal period. Neonatal sepsis has been categorized into two groups: early onset if it occurs within 3-6 days and late onset after 4-7 days. Due to the not-specific clinical signs, along with the inaccuracy of available biomarkers, the diagnosis is still a major challenge. In this regard, the use of a combined approach based on both nuclear magnetic resonance (H-1-NMR) and gas-chromatography-mass spectrometry (GC-MS) techniques, coupled with a multivariate statistical analysis, may help to uncover features of the disease that are still hidden. The objective of our study was to evaluate the capability of the metabolomics approach to identify a potential metabolic profile related to the neonatal septic condition. The study population included 25 neonates (15 males and 10 females): 9 (6 males and 3 females) patients had a diagnosis of sepsis and 16 were healthy controls (9 males and 7 females). This study showed a unique metabolic profile of the patients affected by sepsis compared to non-affected ones with a statistically significant difference between the two groups (p = 0.05). (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)S78-S83
Number of pages6
JournalEARLY HUMAN DEVELOPMENT
Volume90
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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