Background: Congenital hypothyroidism (CH) is an endocrine disease with a precocious signiﬁcant impairment of growth and neuromotor development. Thyroid hormones are essential for central nervous system development, maturation, and myelination. Furthermore, thyroid hormone deﬁciency aﬀects the function of several systems, including the musculoskeletal system. The disease has a signiﬁcant incidence in the general population (1:3000–1:2000newbornsinItaly). The aim of the present study was to evaluate any diﬀerences in upper and lower limb strength, body sway, and plantar loading distribution in children with CH compared to healthy children. Methods: In this study, the case group was composed of children with CH (CHG), while the control group included healthy children (CG).Both groups comprised 19 children (CHG: female =12; CG: female=9). The maximum isometric hand grip strength and explosive-elastic lower limb strength were assessed with the hand grip test and the Sargent test, respectively. The stabilometric and baropodometric analyses were used to measure the Center of Pressure displacements and the plantar loading distribution between feet, respectively. The diﬀerences between groups were analyzed by a univariate analysis of covariance using as covariates weight and height with the signiﬁcant level set at < 0.05. Results: We found that CHG children were shorter and thinner than CG ones (p < 0.05). No signiﬁcant diﬀerence in the upper and lower limb strength was found between groups. CHG exhibited a signiﬁcant greater Sway Path Length (p < 0.01) and Ellipse Surface (p < 0.05) than CG. Moreover, CHG displayed an asymmetric plantar loading distribution with a signiﬁcant lower percentage in the right than in the left foot (p < 0.05). Moreover, a signiﬁcant lower plantar loading percentage in the right foot of CHG than in the right foot of CG was observed (p < 0.05). Conclusions: These ﬁndings seem to suggest that CH does not aﬀect muscle strength in early treated children. However, these patients show poor postural control ability and asymmetric plantar loading distribution. Increasing the physical activity in these children could improve their body posture.
|Number of pages||10|
|Journal||International Journal of Environmental Research and Public Health|
|Publication status||Published - 2020|
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Palma, A., Zangla, D., Bellafiore, M., Corsello, G., Maggio, M. C., Giustino, V., Iovane, A., Thomas, E., Messina, G., & Brusa, J. (2020). Upper and lower limb strength and body posture in children with congenital hypothyroidism: An observational case-control study. International Journal of Environmental Research and Public Health, 17, 1-10.