Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

Giovanni Savettieri, Giuseppe Salemi, Italia Di Liegro, Donatella Ferraro, Alessandro Cestelli, Donatella Ferraro, Roberto Gristina, Daniele Castiglia, Italia Di Liegro, Alessandro Cestelli

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18 Citations (Scopus)

Abstract

Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved
Original languageEnglish
Pages (from-to)1053-1059
Number of pages7
JournalJournal of Neurochemistry
Volume48
Publication statusPublished - 1987

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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