Transformation of primary human hepatocytes in hepatocellular carcinoma.

Mauro Montalbano, Tiziana Corsello, Renza Vento, Tiziana Corsello, Mauro Montalbano, Mahmoud A. Eltorky, Cristiana Rastellini, Luca Cicalese, Renza Vento, Xiaofu Wang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The present study investigated primary human hepatocyte cultures obtained from liver specimens of patients affected by cirrhosis and HCC, their proliferation and transformation. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a transwell migration assay. With the present study, we are the first to have identified and describe the existence of humanhepatocytes near the cancerous lesion that can transform in HCC in vitro.
Original languageEnglish
Pages (from-to)1205-1217
Number of pages13
JournalInternational Journal of Oncology
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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