Transcranial direct current stimulation for treatment of freezing of gait: a cross-over study.

Giovanni Savettieri, Filippo Brighina, Brigida Fierro, Francesca Valentino, Marco D'Amelio, Giuseppe Cosentino, Nicolò Gabriele Pozzi, Claudio Pacchetti, Giorgio Sandrini

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)


BACKGROUND AND OBJECTIVE:Progression of Parkinson's disease (PD) is frequently characterized by the occurrence of freezing of gait (FOG) representing a disabling motor complication. We aim to investigate safety and efficacy of transcranial direct current stimulation of the primary motor cortex of PD patients with FOG.METHODS:In this cross-over, double-blind, sham-controlled study, 10 PD patients with FOG persisting in "on" state underwent anodal and sham direct current stimulation for 5 consecutive days. Clinical assessment over a 1-month period was performed.RESULTS:A significant improvement of gait, as assessed by the Stand Walk Sit test, with reduction in number and duration of FOG episodes, along with a significant reduction in the Unified Parkinson's Disease Rating Scale score, were observed after anodal stimulation. Beneficial effects were more evident after the entire 5-day stimulation session, and persisted until the end of the observation period.CONCLUSIONS:Anodal transcranial direct current stimulation of the motor cortex is safe and has therapeutic potential in PD patients with FOG.
Original languageEnglish
Pages (from-to)1064-1069
Number of pages6
JournalMovement Disorders
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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